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To address this issue analog of TMPyP4, it was synthesized known as 5Me which targets only G quadruplex DNA which inhibits cancer growth more effectively than TMPyP4. [ 74 ] Ligand design and development remains an important field of research into therapeutic reagents due to the abundance of G-quadruplexes and their multiple conformational ...
As a nucleic acid structure, i-motif DNA stability is dependent on the nature of the sequence, temperature, and ionic strength. The structural stability of i-motif DNA is mainly reliant on the fact that there is minimal overlap between the six-membered aromatic pyrimidine bases due to the consecutive base pairs' intercalative geometry.
Peter M Lansdorp. Peter Michael Lansdorp (born December 16, 1952) is recognized for his contributions in the fields of hematology, medical genetics and cancer research.He has made significant contributions to the understanding of genome instability, particularly in relation to aging and cancer.
22427 Ensembl ENSG00000165392 ENSMUSG00000031583 UniProt Q14191 O09053 RefSeq (mRNA) NM_000553 NM_001122822 NM_011721 RefSeq (protein) NP_000544 NP_001116294 NP_035851 Location (UCSC) Chr 8: 31.03 – 31.18 Mb Chr 8: 33.72 – 33.88 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Werner syndrome ATP-dependent helicase, also known as DNA helicase, RecQ-like type 3, is an enzyme that ...
This work lead to a high-resolution structure of a DNA quadruplex [3] and structural studies on protein-drug complexes, such as that of diaphorase with CB1954 (ChesterBeatty 1954), an anticancer prodrug. Neidle was appointed to the Chair of Biophysics at ICR in 1990, and then made Academic Dean 1997–2002. [4]
Oncogenomics is a sub-field of genomics that characterizes cancer-associated genes.It focuses on genomic, epigenomic and transcript alterations in cancer. Cancer is a genetic disease caused by accumulation of DNA mutations and epigenetic alterations leading to unrestrained cell proliferation and neoplasm formation.
Multi-stranded DNA microarrays (triplex-DNA microarrays and quadruplex-DNA microarrays) Multi-stranded DNA and RNA microarrays can be used to identify novel drugs that bind to these multi-stranded nucleic acid sequences. This approach can be used to discover new drugs and biologicals that have the ability to inhibit gene expression.
DNA methylation in cancer plays a variety of roles, helping to change the healthy cells by regulation of gene expression to a cancer cells or a diseased cells disease pattern. One of the most widely studied DNA methylation dysregulation is the promoter hypermethylation where the CPGs islands in the promoter regions are methylated contributing ...
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