Search results
Results from the WOW.Com Content Network
The androgen backdoor pathways occur without the involvement of testosterone (T) and/or androstenedione (A4), which are part of the conventional, canonical (classic) [30] [31] [11] androgenic pathway. [15] In the canonical pathways of androgen biosynthesis, DHT is synthesized from T via 5α-reduction, so that 5α-reduction of T, a C
In other projects Appearance. move to sidebar hide ... Schematic diagram of the androgen biosynthesis via the canonical, backdoor, and 11-oxyback door pathways.
The androgen backdoor pathway (red arrows) roundabout testosterone embedded in within conventional androgen synthesis that lead to 5α-dihydrotestosterone through testosterone. [ 7 ] [ 8 ] [ 9 ] 5α-Pregnan-17α-ol-3,20-dione (17-OH-DHP) is a progestogen , i.e., it binds to the progesterone receptors .
Dihydrotestosterone (DHT) is a metabolite of testosterone, and a more potent androgen than testosterone in that it binds more strongly to androgen receptors. It is produced in the skin and reproductive tissue. A4 and testosterone can also have an extra hydroxyl (-OH) or keton (=O) group bound on position 11.
5α-Reductase (1, 2, 3) – androgen and neurosteroid synthesis, progestogen metabolism; 5β-Reductase – androgen and progestogen metabolism, neurosteroid synthesis; Conjugation (and deconjugation) Glucuronosyltransferase – steroid metabolism [6] Glucuronidase (β-glucuronidase) – steroid synthesis [7]
It functions as a metabolic intermediate in the biosynthesis of the androgen and estrogen sex steroids both in the gonads and in various other tissues. [ 4 ] [ 8 ] [ 9 ] However, DHEA also has a variety of potential biological effects in its own right, binding to an array of nuclear and cell surface receptors , [ 10 ] and acting as a ...
Testosterone: a hormone with a wide variety of effects, ranging from enhancing muscle mass and stimulation of cell growth to the development of the secondary sex characteristics. Dihydrotestosterone (DHT): a metabolite of testosterone, and a more potent androgen than testosterone in that it binds more strongly to androgen receptors.
English: *Enzymes, their cellular location, substrates and products in human steroidogenesis. Shown also is the major classes of steroid hormones: progestagens, mineralocorticoids, glucocorticoids, androgens and estrogens.