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Response to stimuli: a response can take many forms, from the contraction of a unicellular organism to external chemicals, to complex reactions involving all the senses of multicellular organisms. A response is often expressed by motion; for example, the leaves of a plant turning toward the sun (phototropism), and chemotaxis.
The basic unit of the Reactome database is a reaction; reactions are then grouped into causal chains to form pathways [115] The Reactome data model allows us to represent many diverse processes in the human system, including the pathways of intermediary metabolism, regulatory pathways, and signal transduction, and high-level processes, such as ...
Examples of biosynthetic pathways include those for the production of amino acids, lipid membrane components, and nucleotides, but also for the production of all classes of biological macromolecules, and of acetyl-coenzyme A, adenosine triphosphate, nicotinamide adenine dinucleotide and other key intermediate and transactional molecules needed ...
Examples of mechanoreceptors include baroreceptors which detect changes in blood pressure, Merkel's discs which can detect sustained touch and pressure, and hair cells which detect sound stimuli. Homeostatic imbalances that can serve as internal stimuli include nutrient and ion levels in the blood, oxygen levels, and water levels.
For example, the most widely studied bacterium, E. coli strain K-12, is able to produce about 2,338 metabolic enzymes. [1] These enzymes collectively form a complex web of reactions comprising pathways by which substrates (including nutients and intermediates) are converted to products (other intermediates and end-products).
An example progress curve for an enzyme assay is shown above. The enzyme produces product at an initial rate that is approximately linear for a short period after the start of the reaction. As the reaction proceeds and substrate is consumed, the rate continuously slows (so long as the substrate is not still at saturating levels).
In biochemistry, the committed step (also known as the first committed step) is an effectively irreversible, enzyme-catalyzed reaction that occurs at a branch point during the biosynthesis of some molecules. [1] [2] As the name implies, after this step, the molecules are "committed" to the pathway and will ultimately end up in the pathway's ...
Similar reactions will occur far faster if the reaction is intramolecular. The effective concentration of acetate in the intramolecular reaction can be estimated as k 2 /k 1 = 2 x 10 5 Molar. However, the situation might be more complex, since modern computational studies have established that traditional examples of proximity effects cannot be ...
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