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Famotidine, sold under the brand name Pepcid among others, is a histamine H 2 receptor antagonist medication that decreases stomach acid production. [4] It is used to treat peptic ulcer disease , gastroesophageal reflux disease , and Zollinger–Ellison syndrome . [ 4 ]
Ranitidine has 10% of the affinity that cimetidine has to CYP450, so it causes fewer side effects, but other H 2 blockers famotidine and nizatidine have no CYP450 significant interactions. [131] Ranitidine was introduced in 1981, and was the world's biggest-selling prescription drug by 1987. [132]
Cimetidine was the prototypical histamine H 2 receptor antagonist from which later drugs were developed. Cimetidine was the culmination of a project at Smith, Kline & French (SK&F; now GlaxoSmithKline) by James W. Black, C. Robin Ganellin, and others to develop a histamine receptor antagonist that would suppress stomach acid secretion.
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By Brendan Pierson (Reuters) -A Delaware judge has allowed more than 70,000 lawsuits over discontinued heartburn drug Zantac to go forward, ruling that expert witnesses can testify in court that ...
The U.S. Food and Drug Administration (FDA) in 2020 pulled Zantac and its generic versions off the market, triggering a wave of lawsuits. GSK settles another Zantac lawsuit in California Skip to ...
They are mediators and have a variety of strong physiological effects, such as regulating the contraction and relaxation of smooth muscle tissue. [8] There are many prostaglandins with many effects. Prostaglandin E2 has effects including reducing gastric acid and increasing gastric mucus, which among other effects treat acid-related disorders. [9]
No reliable studies link Zantac use to cancer, Cheffo said, a view shared by all the defendants. Instead, he said, plaintiffs rely on a finding that Zantac's active ingredient, ranitidine, can ...
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