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Signal Transduction and Targeted Therapy is a multidisciplinary peer-reviewed open access scientific journal covering biomedical research with a particular focus on signal transduction and its application to the drug development process. It was established in 2016 and is published by Nature Research.
Impact factor. 41.444 (2021) Standard abbreviations ... molecular oncology, cancer genetics, epigenetics, signal transduction, and targeted therapy. ...
As of 2022 Revolution Medicines was exploring a small molecule therapy and reported anti-tumor activity in KRAS-G12D mutant tumor models. [ 63 ] In 2021, the first clinical trial of a gene therapy targeting KRAS G12D was recruiting patients, sponsored by the National Cancer Institute .
596 12043 Ensembl ENSG00000171791 ENSMUSG00000057329 UniProt P10415 P10417 RefSeq (mRNA) NM_000633 NM_000657 NM_009741 NM_177410 RefSeq (protein) NP_000624 NP_000648 NP_033871 NP_803129 Location (UCSC) Chr 18: 63.12 – 63.32 Mb Chr 1: 106.47 – 106.64 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Bcl-2, encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 ...
mTOR inhibitors are a class of drugs used to treat several human diseases, including cancer, autoimmune diseases, and neurodegeneration. They function by inhibiting the mammalian target of rapamycin (mTOR) (also known as the mechanistic target of rapamycin), which is a serine/threonine-specific protein kinase that belongs to the family of phosphatidylinositol-3 kinase (PI3K) related kinases ...
The Journal of Receptors and Signal Transduction is a peer-reviewed scientific journal that publishes laboratory and clinical studies, reviews, and brief communications on biological receptors and associated signal transduction pathways for ligands involved in the regulation of central and peripheral tissues and cells.
The Janus kinase (JAK)/signal transducer and the activator of the transcription pathway were at the centre of attention for driving hyperinflammation in COVID-19, i.e., the SARS-CoV-2 infection triggers hyperinflammation through the JAK/STAT pathway, resulting in the recruitment of dendritic cells, macrophages, and natural killer (NK) cells, as ...
These enzymes play a crucial role in signal transduction within the cell. Under normal conditions, JNK is activated by the phosphorylation of threonine and tyrosine residues. [ 32 ] [ 33 ] However, studies on specific cell lines derived from patients with acute promyelocytic leukemia have demonstrated that this activation also occurs in ...