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The concept of replacing hydrogen with deuterium is an example of bioisosterism, whereby similar biological effects to a known drug are produced in an analog designed to confer superior properties. [5]
International Journal of Pharma and Bio Sciences; International Journal of Pharmaceutics; Journal of Biomedical Nanotechnology; The Journal of Clinical Pharmacology; Journal of Controlled Release; Journal of Ethnopharmacology; Journal of Generic Medicines; Journal of Microencapsulation; Journal of Oncology Pharmacy Practice; Journal of Pharmacy ...
The exchange reaction can be followed using a variety of methods (see Detection). Since this exchange is an equilibrium reaction, the molar amount of deuterium should be high compared to the exchangeable protons of the substrate. For instance, deuterium is added to a protein in H 2 O by diluting the H 2 O solution with D 2 O (e.g. tenfold ...
Deuterated acetone is prepared by the reaction of acetone with heavy water, 2 H 2 O or D 2 O, in the presence of a base. In this case, the base used is deuterated lithium hydroxide : [ 1 ] In order to fully deuterate the acetone, the process is repeated several times, distilling off the acetone from the heavy water, and re-running the reaction ...
The International Journal of Pharmaceutics is a peer-reviewed medical journal covering physical, chemical, biological, microbiological, and engineering studies related to the conception, design, production, characterization, and evaluation of drug delivery systems in vitro and in vivo.
The journal was established in 1966 as the Australian Journal of Hospital Pharmacy with Fred J. Boyd and Charles B Macgibbon as the founding editors-in-chief. [2] The journal obtained its current title in 2002. Since 2014, the journal is published by John Wiley & Sons on behalf of the SHPA. [3]
The Journal of Pharmacy and Pharmacology is a monthly peer-reviewed scientific journal covering all aspects of pharmacy and pharmacology. It is published by Wiley-Blackwell on behalf of the Royal Pharmaceutical Society. It is an official journal of the British Pharmaceutical Conference. It was established in 1870 and acquired its current title ...
The Journal of Pharmacy & Pharmaceutical Sciences is an open access peer-reviewed medical journal covering all aspects of pharmacy and pharmaceutical sciences. It was established in 1998, and is published by Frontiers Media on behalf of the Canadian Society for Pharmaceutical Sciences. The editor-in-chief is Fakhreddin Jamali (University of ...