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The blood–brain barrier is formed by the brain capillary endothelium and excludes from the brain 100% of large-molecule neurotherapeutics and more than 98% of all small-molecule drugs. [28] Overcoming the difficulty of delivering therapeutic agents to specific regions of the brain presents a major challenge to treatment of most brain disorders.
Neurotoxic behavior of Aluminium is known to occur upon entry into the circulatory system, where it can migrate to the brain and inhibit some of the crucial functions of the blood brain barrier (BBB). [37] A loss of function in the BBB can produce significant damage to the neurons in the CNS, as the barrier protecting the brain from other ...
The mechanism of how certain foods interfere with brain health is still unclear. ... such as damage to vascular health or brain cell injury, but no research has yet to find the direct link between ...
The researchers gave the participants cognitive tests every 18 months, and also tested them for signs of neurodegeneration (the loss of brain and nervous system function).
Diets rich in four different types of nutrients may help reduce iron buildup in the brain and lower the risk of cognitive decline that comes with aging, a new study suggests.
Furthermore, they allow the formation of the blood–brain barrier by inhibiting the effects of CNS immune cells (which can damage the formation of the barrier) and by reducing the expression of molecules that increase vascular permeability. [23] Aside from blood–brain barrier formation, pericytes also play an active role in its functionality.
Replacing red meat with plant-based protein sources such as nuts and legumes was associated with a 19% lower risk of dementia and 1.37 fewer years of cognitive aging, according to the study.
Damage by glycation results in stiffening of the collagen in the blood vessel walls, leading to high blood pressure, especially in diabetes. [11] Glycations also cause weakening of the collagen in the blood vessel walls, [ 12 ] which may lead to micro- or macro-aneurysm; this may cause strokes if in the brain.