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Neurotrophic factors also promote the initial growth and development of neurons in the central nervous system and peripheral nervous system, and they are capable of regrowing damaged neurons in test tubes and animal models. [1] [4] Some neurotrophic factors are also released by the target tissue in order to guide the growth of developing axons.
According to the United States National Library of Medicine's medical subject headings, the term neurotrophin may be used as a synonym for neurotrophic factor, [5] but the term neurotrophin is more generally reserved for four structurally related factors: nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4). [6]
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Neurotrophic factors are biomolecules – nearly all of which are peptides or small proteins – that support the growth, survival, and differentiation of both developing and mature neurons. [2] [3] [4] Examples of notable neurotrophic factors include: Insulin-like growth factor-1 (IGF-1) Glial cell line-derived neurotrophic factor (GDNF)
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The common ligands of trk receptors are neurotrophins, a family of growth factors critical to the functioning of the nervous system. [3] The binding of these molecules is highly specific. Each type of neurotrophin has different binding affinity toward its corresponding Trk receptor. The activation of Trk receptors by neurotrophin binding may ...
The protein encoded by this gene, NT-3, is a neurotrophic factor in the NGF (Nerve Growth Factor) family of neurotrophins. It is a protein growth factor which has activity on certain neurons of the peripheral and central nervous system ; it helps to support the survival and differentiation of existing neurons, and encourages the growth and ...
Tropomyosin receptor kinase B is the high affinity catalytic receptor for several "neurotrophins", which are small protein growth factors that induce the survival and differentiation of distinct cell populations. The neurotrophins that activate TrkB are: BDNF (Brain Derived Neurotrophic Factor), neurotrophin-4 (NT-4), and neurotrophin-3 (NT-3).