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Use in pregnancy and breastfeeding is not recommended. [3] Losartan works by blocking the effects of angiotensin II while hydrochlorothiazide works by decreasing the ability of the kidneys to absorb electrolytes. [1] The combination was approved for medical use in the United States in 1995. [1] It is available as a generic medication. [2]
Up to six weeks may be required for the full effects to occur. [4] Common adverse effects include muscle cramps, stuffy nose, dizziness, cough, high blood potassium, and anemia. [4] Severe adverse effects may include angioedema, low blood pressure, and kidney problems. [4] Use during pregnancy may result in harm to the baby.
There is an increased risk of non-melanoma skin cancer. [29] In August 2020, the Australian Therapeutic Goods Administration required the Product Information (PI) and Consumer Medicine Information (CMI) for medicines containing hydrochlorothiazide to be updated to include details about an increased risk of non-melanoma skin cancer. [30]
A woman who miscarried was fined by the NHS for claiming a free prescription while pregnant.. Sadie Hawkes, 33, lost her baby before she had received the maternity exemption certificate that ...
The use of valsartan in pregnancy is avoided due to the potential risk of fetal toxicity. [11] The U.S. Food and Drug Administration has a black box warning for valsartan/hydrochlorothiazide use during pregnancy. [2] The use of hydrochlorothiazide is avoided in those with anuria or severe kidney disease. [12]
Women should speak to their doctor or healthcare professional before starting or stopping any medications while pregnant. [1] Drugs taken in pregnancy including over-the counter-medications, prescription medications, nutritional supplements, recreational drugs, and illicit drugs may cause harm to the mother or the unborn child.
Medical reasons for inducing or performing an abortion are usually due to concerns about fetal viability or disability. These reasons include chromosomal and genetic abnormalities, [6] structural abnormalities, [7] and fetal reduction. [8] The medical reasons may also be about the ability of the mother to survive the pregnancy without injury.
In April of 2022, Pfizer voluntarily recalled five batches of the drug because of the presence of a nitrosamine, N-Nitroso-quinapril.Testing found that the amount of nitrosamines was above the acceptable daily intake level (all humans are exposed to nitrosamines up to a certain daily level by cured and grilled meats, water, dairy products, and vegetables) set by the U.S.'s Food and Drug ...
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