Search results
Results from the WOW.Com Content Network
Thiazolidinedione ligand dependent transactivation is responsible for the majority of anti-diabetic effects. The activated PPAR/RXR heterodimer binds to peroxisome proliferator hormone response elements upstream of target genes in complex with a number of coactivators such as nuclear receptor coactivator 1 and CREB binding protein, this causes upregulation of genes (for a full list see PPARγ):
the article about bibliographic databases for information about databases giving bibliographic information about finding books and journal articles. Note that "free" or "subscription" can refer both to the availability of the database or of the journal articles included. This has been indicated as precisely as possible in the lists below.
Stress is a bimonthly peer-reviewed medical journal covering research on stress in terms of: the mechanisms of stressful stimulation, the physiological and behavioural responses to stress, and their regulation, in both the short and long term; adaptive mechanisms, and the pathological consequences of stress. This includes research in physiology ...
Action Research is a quarterly peer-reviewed academic journal that covers the field of action research. The journal was established in 2003 and is published by SAGE Publications . The editor-in-chief is Hilary Bradbury ( AR+ Foundation ).
The best-known PPAR ligands are the thiazolidinediones. After PPARδ (delta) was identified in humans in 1992, [9] it turned out to be closely related to PPARβ (beta), previously described during the same year in an amphibian, Xenopus.
The journal was established in 1987 by founding editor-in-chief Tom Cox (Birkbeck, University of London). [1] The first volumes were principally concerned with work and stress, "the central focus of occupational health psychology". [2] The journal's scope expanded over time to cover more occupational health psychology-related topics. [1]
Thiazolidinediones act as insulin sensitizers. They reduce glucose, fatty acid, and insulin blood concentrations. They work by binding to the peroxisome proliferator-activated receptors (PPARs). PPARs are transcription factors that reside in the nucleus and become activated by ligands such as thiazolidinediones.
Thiazolidines functionalized with carbonyls at the 2 and 4 positions, the thiazolidinediones, are drugs used in the treatment of diabetes mellitus type 2. Rhodanine is a related bioactive species, featuring one carbonyl and one thiocarbonyl. Many thiazolidines are prepared from cysteine and related aminothiols.