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The majority of engineered zinc finger arrays are based on the zinc finger domain of the murine transcription factor Zif268, although some groups have used zinc finger arrays based on the human transcription factor SP1. Zif268 has three individual zinc finger motifs that collectively bind a 9 bp sequence with high affinity. [30]
The majority of engineered zinc finger arrays are based on the zinc finger domain of the murine transcription factor Zif268, although some groups have used zinc finger arrays based on the human transcription factor SP1. Zif268 has three individual zinc finger motifs that collectively bind a 9 bp sequence with high affinity. [12]
Zinc finger" : Cartoon representation of the zinc-finger motif of proteins. The zinc ion (green) is coordinated by two histidine and two cysteine amino acid residues. CCHH-type zinc-finger domains are the most common DNA-binding domain within the eukaryotic genome. In order to attain high sequence-specific recognition of DNA, several zinc ...
The ZZ-type zinc finger of CBP contains two twisted anti-parallel beta-sheets and a short alpha-helix, and binds two zinc ions. [2] One zinc ion is coordinated by four cysteine residues via 2 Cys-X2-Cys motifs, and the third zinc ion via a third Cys-X-Cys motif and a His-X-His motif. The first zinc cluster is strictly conserved, whereas the ...
n/a Ensembl ENSG00000147117 n/a UniProt P51786 n/a RefSeq (mRNA) NM_003446 n/a RefSeq (protein) NP_003437 n/a Location (UCSC) Chr X: 47.37 – 47.41 Mb n/a PubMed search n/a Wikidata View/Edit Human Zinc finger protein 157 is a protein that in humans is encoded by the ZNF157 gene. Function This gene product is a likely zinc finger family transcription factor. It contains KRAB-A and KRAB-B ...
CpG-binding protein (CGBP) also known as CXXC-type zinc finger protein 1 (CXXC1) or PHD finger and CXXC domain-containing protein 1 (PCCX1) is a protein that in humans is encoded by the CXXC1 gene. [5] [6] [7] Proteins that contain a CXXC motif within their DNA-binding domain, such as CXXC1, recognize CpG sequences and regulate gene expression. [6]
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