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Prurigo nodularis (PN), also known as nodular prurigo, is a skin disorder characterized by pruritic , nodular lesions, which commonly appear on the trunk, arms and legs. [1] Patients often present with multiple excoriated nodules caused by chronic scratching.
Prurigo is a reactive skin condition distinguished by numerous, isolated itchy papules. [1] The word "prurigo" comes from the Latin word pruire, which meaning itching. Ferdinand von Hebra coined the term "prurigo" in Vienna in 1850 to describe papules and nodules that had severe pruritus . [ 2 ]
Acariasis is a term for a rash, caused by mites, sometimes with a papillae (pruritic dermatitis) or papule (papular urticaria), and usually accompanied by a hive and severe itching sensations. An example of such an infection is scabies or gamasoidosis. [citation needed]
The skin eruptions are often pruritic and accompanied by fever, headache, a high number of neutrophils and eosinophils in the blood, and elevated blood levels of markers for inflammation (i.e. erythrocyte sedimentation rate and C-reactive protein). The skin eruptions typically end within a week after causative drug is discontinued.
Common symptoms include pruritic erythematous papules, [3] with a size of 1–3 mm, [4] and a central punctum, [5] as well as macules and urticaria. [2] Individuals frequently describe repeated or long-term episodes of papular outbreaks, often appearing in clusters and accompanied by severe itching sensations. [ 6 ]
The skin weighs an average of four kilograms, covers an area of two square metres, and is made of three distinct layers: the epidermis, dermis, and subcutaneous tissue. [1] The two main types of human skin are: glabrous skin, the hairless skin on the palms and soles (also referred to as the "palmoplantar" surfaces), and hair-bearing skin. [3]
Prurigo gestationis is an eruption consisting of pruritic, excoriated papules of the proximal limbs and upper trunk, most often occurring between the 20th and 34th week of gestation. [3] [2] [4] [5] The exact etiology is unknown, but it is considered likely to be a flareup of atopic dermatitis during pregnancy. [6]
Dermatoses of pregnancy are the inflammatory skin diseases that are specific to women while they are pregnant. [1] While some use the term 'polymorphic eruption of pregnancy' to cover these, [2] this term is a synonym used in the UK for Pruritic urticarial papules and plaques of pregnancy, [3] which is the commonest of these skin conditions.