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Hydroxyapatite (IMA name: hydroxylapatite [5]) (Hap, HAp, or HA) is a naturally occurring mineral form of calcium apatite with the formula Ca 5 (PO 4) 3 (OH), often written Ca 10 (PO 4) 6 (OH) 2 to denote that the crystal unit cell comprises two entities. [6]
Hydroxyapatite, also known as hydroxylapatite, is the major component of tooth enamel and bone mineral. A relatively rare form of apatite in which most of the OH groups are absent and containing many carbonate and acid phosphate substitutions is a large component of bone material.
The primary mineral is hydroxyapatite, which is a crystalline calcium phosphate. [4] Enamel is formed on the tooth while the tooth develops within the jaw bone before it erupts into the mouth. Once fully formed, enamel does not contain blood vessels or nerves, and is not made of cells.
hydroxyapatite, Ca 5 (PO 4) 3 OH; octacalcium phosphate, Ca 8 H 2 (PO 4) 6 · 5 H 2 O; and brushite, CaHPO 4 · 2 H 2 O; The organic component is approximately 85% cellular and 15% extracellular matrix. [5] Cell density within dental plaque and calculus is very high, consisting of an estimated 200,000,000 cells per milligram.
P11-4 is a self-assembling β-peptide. It builds a 3-D bio-matrix with binding sites for Calcium-ions serving as nucleation point for hydroxyapatite (tooth mineral) formation. The high affinity to tooth mineral is based on matching distances of Ca-ion binding sites on P11-4 and Ca spacing in the crystal lattice of hydroxyapatite.
Polarizing microscopy and application of other crystallographic techniques have improved identification of different microcrystals including monosodium urate, calcium pyrophosphate dihydrate, calcium hydroxyapatite, and calcium oxalate. [1]
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Ossein-hydroxyapatite is a composite of collagen protein (ossein) and hydroxyapatite. Ossein-hydroxyapatite exhibits high stability and is less soluble in water compared to other calcium compounds. Microcrystalline hydroxyapatite is extracted from bovine bone and contains the mineral matrix found in human bones.