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Acarbose also blocks pancreatic alpha-amylase in addition to inhibiting membrane-bound alpha-glucosidases. Pancreatic alpha-amylase hydrolyzes complex starches to oligosaccharides in the lumen of the small intestine. Inhibition of these enzyme systems reduces the rate of digestion of carbohydrates.
Gymnema sylvestre [1] is a perennial woody vine native to Asia (including the Arabian Peninsula), Africa and Australia. It has been used in Ayurvedic medicine.Common names include gymnema, [2] Australian cowplant, and Periploca of the woods, and the Hindi term gurmar, which means "sugar destroyer".
Acarbose is a starch blocker. It works by inhibiting alpha glucosidase, an intestinal enzyme that releases glucose from larger carbohydrates such as starch and sucrose. It is composed of an acarviosin moiety with a maltose at the reducing terminus. It can be degraded by a number of gut bacteria. [3]
As long as we get our daily dose of sugar, we feel like kids in a candy shop. On the flip side, we’re also concerned with our health. Sugar may be delicious, but it’s also dangero.
In the sugar analogues of dapagliflozin, the β-C series are more active than α-C series so it is critical that the β-configuration is at C-1 for the inhibitory activity. [55] Both dapagliflozin and empagliflozin contain a chlorine (Cl) atom in their chemical structure. Cl is a halogen and it has a high electronegativity. This ...
Berries are excellent for managing blood sugar because of their fiber content, offering, on average, 3 grams of fiber for every cup. Thaw berries as a topping for Multi-Grain Waffles or toss into ...
Lipase inhibitors may affect the amount of fat absorbed, yet they do not block the absorption of a particular type of fat. [1] Likewise, lipase inhibitors are not absorbed into the bloodstream. Lipase inhibitors bind to lipase enzymes in the intestine, [2] thus preventing the hydrolysis of dietary triglycerides into monoglycerides and fatty ...
To help avoid such risks, suggests Cathi Dennehy, a doctor of pharmacy, dietary supplement researcher, and professor at the University of California San Francisco, start by speaking with your ...
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