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Doxycycline was patented in 1957 and came into commercial use in 1967. [7] [8] It is on the World Health Organization's List of Essential Medicines. [9] Doxycycline is available as a generic medicine. [1] [10] In 2022, it was the 68th most commonly prescribed medication in the United States, with more than 9 million prescriptions. [11] [12]
[42] [43] Antibiotics should also be used at the lowest dose for the shortest course. For example, research in the UK has shown that a 3-day course of antibiotics (amoxicillin) was as effective as 7-day course for treating children with pneumonia. [44] [45]
[6] [7] Tetracyclines are widely used in the treatment of moderately severe acne and rosacea (tetracycline, oxytetracycline, doxycycline or minocycline). [8] Anaerobic bacteria are not as susceptible to tetracyclines as are aerobic bacteria. [9]
However, the combination of choice according to current research is a combination of amoxicillin (500 mg, thrice/day) and metronidazole (200 mg, thrice/day), for 7 days, starting on the day of the final debridement. Doxycycline (100 mg, once/day, with a starting first dose of 200 mg) is the choice of antibiotics for patients allergic to penicillin.
The course of a disease, also called its natural history, [3] is the development of the disease in a patient, including the sequence and speed of the stages and forms they take. [4] Typical courses of diseases include: chronic; recurrent or relapsing; subacute: somewhere between an acute and a chronic course
Amoxicillin is in the β-lactam family of antibiotics. [9] Amoxicillin was discovered in 1958 and came into medical use in 1972. [12] [13] Amoxil was approved for medical use in the United States in 1974, [4] [5] and in the United Kingdom in 1977. [2] It is on the World Health Organization's List of Essential Medicines. [14]
In 2001, the WHO recommended oral doxycycline (2 mg/kg up to 100 mg every 12 hours) for five to seven days for those with mild leptospirosis. Tetracycline, ampicillin, and amoxicillin can also be used in such cases. [43] However, in areas where both rickettsia and leptospirosis are endemic, azithromycin and doxycycline are the drugs of choice. [8]
Among Swedish patients, doxycycline was shown to be relatively ineffective (with a cure rate of 48% for women and 38% for men); and treatment with a single dose of azithromycin is not prescribed due to it inducing antimicrobial resistance. The five-day treatment with azithromycin showed no development of antimicrobial resistance. [49]
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