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Interstitial lung disease affects gas flow in the alveoli The alveoli Micrograph of usual interstitial pneumonia (UIP). UIP is the most common pattern of idiopathic interstitial pneumonia (a type of interstitial lung disease) and usually represents idiopathic pulmonary fibrosis.
Alveolar lung disease may be divided into acute or chronic. Causes of acute alveolar lung disease include pulmonary edema (cardiogenic or neurogenic), pneumonia (bacterial or viral), systemic lupus erythematosus, [2] bleeding in the lungs (e.g., Goodpasture syndrome), [3] idiopathic pulmonary hemosiderosis, [4] and granulomatosis with polyangiitis.
A pulmonary consolidation is a region of normally compressible lung tissue that has filled with liquid instead of air. [1] The condition is marked by induration [2] (swelling or hardening of normally soft tissue) of a normally aerated lung.
The filling of air spaces by the exudate leads to a gross appearance of solidification, or consolidation, of the alveolar parenchyma. This appearance has been likened to that of the liver, hence the term "hepatization". Grey hepatization: Red blood cells disintegrate, with the persistence of neutrophils and fibrin. The alveoli still appear ...
A pulmonary infiltrate is a substance denser than air, such as pus, blood, or protein, which lingers within the parenchyma of the lungs. [1] Pulmonary infiltrates are associated with pneumonia, tuberculosis, [citation needed] and sarcoidosis. [2] Pulmonary infiltrates can be observed on a chest radiograph. [citation needed]
Pulmonary infiltrates that resolved after giving mechanical ventilation should point to heart failure and atelectasis rather than pneumonia. For recurrent pneumonia, underlying lung cancer, metastasis , tuberculosis, a foreign bodies, immunosuppression, and hypersensitivity should be suspected.
Diffuse alveolar damage (DAD) is a histologic term used to describe specific changes that occur to the structure of the lungs during injury or disease. Most often DAD is described in association with the early stages of acute respiratory distress syndrome ( ARDS ). [ 1 ]
In addition, a biopsy of the lung that shows organizing diffuse alveolar damage is required for diagnosis. This type of alveolar damage can be attributed to nonconcentrated and nonlocalized alveoli damage, marked alveolar septal edema with inflammatory cell infiltration, fibroblast proliferation, occasional hyaline membranes, and thickening of ...