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Cefalexin, also spelled cephalexin, is an antibiotic that can treat a number of bacterial infections. [4] It kills gram-positive and some gram-negative bacteria by disrupting the growth of the bacterial cell wall. [4] Cefalexin is a β-lactam antibiotic within the class of first-generation cephalosporins. [4]
Antibiotic candidates Generic name Origin Susceptible phyla Stage of development Mechanism of action Unclassified Teixobactin: Eleftheria terrae: Gram-positive, including antibiotic resistant S. aureus and M. tuberculosis: No human trials scheduled: Binds fatty acid precursors to cell wall Malacidins: Uncultured Bacterium
Cefadroxil is a first-generation cephalosporin antibacterial drug that is the para-hydroxy derivative of cephalexin, and is used similarly in the treatment of mild to moderate susceptible infections such as the bacterium Streptococcus pyogenes, causing the disease popularly called strep throat or streptococcal tonsillitis, urinary tract infection, reproductive tract infection, and skin infections.
Opening of the β-lactam ring by a serine residue in the enzyme binding site leads to covalent binding of the antibiotic molecule with the active site of the enzyme. The result is an inactive irreversibly bound enzyme-complex which is incapable of further cell wall synthesis and the cell will die from osmotic-lysis.
Flucloxacillin, also known as floxacillin, is an antibiotic used to treat skin infections, external ear infections, infections of leg ulcers, diabetic foot infections, and infection of bone. [6] It may be used together with other medications to treat pneumonia, and endocarditis. [6]
cephalexin: Keflex: H V: Gram-positive: Activity against penicillinase-producing, methicillin-susceptible staphylococci and streptococci (though they are not the drugs of choice for such infections). No activity against methicillin-resistant staphylococci or enterococci. [citation needed]
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Acute use (1–3 days) yields a potency about 1.5× stronger than that of morphine and chronic use (7 days+) yields a potency about 2.5 to 5× that of morphine. Similarly, the effect of tramadol increases after consecutive dosing due to the accumulation of its active metabolite and an increase of the oral bioavailability in chronic use.
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