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Baricitinib is a Janus kinase (JAK) inhibitor that reversibly inhibits Janus kinase 1 with a half maximal inhibitory concentration (IC 50) of 5.9 nM and Janus kinase 2 with an IC 50 of 5.7 nM. Tyrosine kinase 2, which belongs to the same enzyme family, is affected less (IC 50 = 53 nM), and Janus kinase 3 far less (IC 50 > 400 nM).
The air raid on Bari (German: Luftangriff auf den Hafen von Bari, Italian: Bombardamento di Bari) was an air attack by German bombers on Allied forces and shipping in Bari, Italy, on 2 December 1943, during World War II. 105 German Junkers Ju 88 bombers of Luftflotte 2 surprised the port's defenders and bombed shipping and personnel operating in support of the Allied Italian Campaign, sinking ...
Antipyrine and benzocaine ear drops is a medication for the treatment of ear pain caused by otitis media. It combines antipyrine, an NSAID, and benzocaine, a local anaesthetic in order to treat ear pain, alongside hydroxyquinoline sulfate, an antiseptic and preservative. Its trade names include Auralgan, Aurodex, Auroto, [ 1 ] among others, and ...
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Società Sportiva Calcio Bari, [2] commonly referred to as Bari, is an Italian football club based in Bari, Apulia. Bari currently plays in the Serie B. The team finished the 2021–22 season in first place in Serie C and earned promotion to Serie B for the 2022–23 season. Bari was originally founded in 1908 and reestablished several times ...
Cardinal Bonvisi was provided by Pope Clement VIII on 18 March 1602, and consecrated by the Pope in the Sistine Chapel in April 1602. He arrived in Bari in the first week of November, and took possession on 7 November. He died some ten months later, on 1 September 1603.
As of 2023, there have been 92 off-season cyclones recorded in the official Atlantic hurricane database, which dates back to 1851. In addition, six earlier such storms have been documented, but are not part of the database. The first off-season storm in the database was an 1865 storm that developed in the Caribbean Sea; an earlier documented ...
The Barí people's chief economic activity is the growing of Theobroma cacao, the plant from which chocolate is made. They export the cacao and use the proceeds to help maintain their network of schools, community centers, and health clinics, all started after large numbers of the Barí (notably the chieftain, "Bobby") converted to Christianity, which resulted in a significant cultural shift.