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Mouse double minute 2 homolog (MDM2) also known as E3 ubiquitin-protein ligase Mdm2 is a protein that in humans is encoded by the MDM2 gene. [ 5 ] [ 6 ] Mdm2 is an important negative regulator of the p53 tumor suppressor.
2020 13799 Ensembl ENSG00000164778 ENSMUSG00000039095 UniProt P19622 P09066 RefSeq (mRNA) NM_001427 NM_010134 NM_001395060 RefSeq (protein) NP_001418 NP_034264 NP_001381989 Location (UCSC) Chr 7: 155.46 – 155.46 Mb Chr 5: 28.37 – 28.38 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Homeobox protein engrailed-2 is a protein that in humans is encoded by the EN2 gene. It is a ...
The mouse HoxA cluster shown here has 11 paralogous genes (2 are missing). [39] Paralogous genes can shape the structure of whole genomes and thus explain genome evolution to a large extent. Examples include the Homeobox genes in animals. These genes not only underwent gene duplications within chromosomes but also whole genome duplications. As ...
The gene targeting method in knockout mice uses mouse embryonic stem cells to deliver artificial genetic material (mostly of therapeutic interest), which represses the target gene of the mouse by the principle of homologous recombination. The mouse thereby acts as a working model to understand the effects of a specific mammalian gene.
DNA mismatch repair protein Msh2 also known as MutS homolog 2 or MSH2 is a protein that in humans is encoded by the MSH2 gene, which is located on chromosome 2.MSH2 is a tumor suppressor gene and more specifically a caretaker gene that codes for a DNA mismatch repair (MMR) protein, MSH2, which forms a heterodimer with MSH6 to make the human MutSα mismatch repair complex.
Human: Mouse: Entrez: Ensembl: UniProt RefSeq (mRNA) RefSeq (protein) NP_001153075 ... Pumilio homolog 1 is a protein that in humans is encoded by the PUM1 gene. [4]
A separate test was conducted on GENSCAN's accuracy using two GeneParser data sets that are stripped of all genes that are more than 25% of a match regarding amino acids with those in previous GeneParser test sets. The resulting data of this test and of the same test performed on other programs is shown in the table below.
PAX6 is a member of the Pax gene family which is responsible for carrying the genetic information that will encode the Pax-6 protein. It acts as a "master control" gene for the development of eyes and other sensory organs, certain neural and epidermal tissues as well as other homologous structures, usually derived from ectodermal tissues.