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XLR-11 (5"-fluoro-UR-144 or 5F-UR-144) is a drug that acts as a potent agonist for the cannabinoid receptors CB 1 and CB 2 with EC 50 values of 98 nM and 83 nM ...
AM-2201 is a full agonist for cannabinoid receptors. Affinities are: with a K i of 1.0 nM at CB 1 and 2.6 nM at CB 2. [6] The 4-methyl functional analog MAM-2201 probably has similar affinities. [original research?] AM-2201 has an EC 50 of 38 nM for human CB 1 receptors, and 58 nM for human CB 2 receptors. [7]
AB-CHMINACA is an indazole-based synthetic cannabinoid.It is a potent agonist of the CB 1 receptor (K i = 0.78 nM) and CB 2 receptor (K i = 0.45 nM) and fully substitutes for Δ 9-THC in rat discrimination studies, while being 16x more potent.
JWH-018 is a full agonist of both the CB 1 and CB 2 cannabinoid receptors, with a reported binding affinity of 9.00 ± 5.00 nM at CB 1 and 2.94 ± 2.65 nM at CB 2. [6] JWH-018 has an EC 50 of 102 nM for human CB 1 receptors, and 133 nM for human CB 2 receptors. [16]
Arachidonyl-2'-chloroethylamide (ACEA) is a synthetic agonist of the CB 1 (CB1R). ACEA is considered to be a selective cannabinoid agonist as it binds primarily to the CB1R and has low affinity to the CB 2 (CB2R) (K i = 1.4 nM for CB1R; K i = 3100 nM for CB2R).
4F-MDMB-BINACA (also known as MDMB-4F-BINACA, [2] 4F-MDMB-BUTINACA) is an indazole-based synthetic cannabinoid from the indazole-3-carboxamide family. [3] It should not be confused with the amantadine analogue 4F-ABINACA. It has been used as an active ingredient in synthetic cannabis products and sold as a designer drug since late 2018.
NNE1 (also known as NNEI, MN-24 and AM-6527) is an indole-based synthetic cannabinoid, representing a molecular hybrid of APICA and JWH-018 [1] that is an agonist for the cannabinoid receptors, with K i values of 60.09 nM at CB 1 and 45.298 nM at CB 2 and EC 50 values of 9.481 nM at CB 1 and 1.008 nM at CB 2. [2]
CUMYL-4CN-BINACA (also known as CUMYL-CYBINACA or SGT-78) is an indazole-3-carboxamide based synthetic cannabinoid that has been sold online as a designer drug. [3 ...