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Coeliac disease appears to be multifactorial, both in that more than one genetic factor can cause the disease and in that more than one factor is necessary for the disease to manifest in a person. [62] Almost all people (95%) with coeliac disease have either the variant HLA-DQ2 allele or (less commonly) the HLA-DQ8 allele.
This can cause a wide variety of secondary problems. Hypocalcinemia is also associated with GSE. [4] In treated GSE, the restrictions on diet as well as reduced absorption as a result of prolonged damage may result in post-treatment deficiencies. [5] Vitamin A – Poor absorption of vitamin A has been seen in coeliac disease.
Autoimmune conditions related to gluten include celiac disease, dermatitis herpetiformis, and gluten ataxia.There is research showing that in people with gluten ataxia early diagnosis and treatment with a gluten-free diet can improve ataxia and prevent its progression. [9]
Possible causes include exocrine pancreatic insufficiency, with poor digestion from lack of lipases, loss of bile salts, which reduces micelle formation, and small intestinal disease-producing malabsorption. Various other causes include certain medicines that block fat absorption or indigestible or excess oil/fat in diet.
For individuals with gluten sensitivity or celiac disease, gluten can trigger an immune response, leading to more inflammation and potentially worsening autoimmune conditions like alopecia areata ...
The symptoms, which include nausea, vomiting, diarrhea, weight loss, and electrolyte abnormalities, are common among those who have celiac disease. [12] Recent studies suggested this form of sprue-like enteropathy could be caused by the inhibition of TGF-β , a polypeptide cytokine that maintains intestinal homeostasis .
There’s also the potential that people with celiac disease may be sensitive to the avenin protein in colloidal oatmeal, and it could cause a rash or an itch for these individuals, Dr. Holman says.
Irritable bowel syndrome, or IBS, is among the most common gastrointestinal conditions today. It affects some 10% to 15% of people in the U.S., per the American College of Gastroenterology. A ...