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RNA-binding proteins ... in a difference in their protein's amino acid sequence. An example of this is the glutamate receptor mRNA where glutamine is converted to ...
Since most mature RNA is exported from the nucleus relatively quickly, most RNA-binding protein in the nucleus exist as heterogeneous ribonucleoprotein particles. After splicing has occurred, the proteins remain bound to spliced introns and target them for degradation.
The perinucleolar compartment was first discovered due to characterizing the polypyrimidine tract-binding protein (PTB), which is an RNA binding protein involved with pre-mRNA splicing, stability, and regulating translation. [7] The PTB and other binding proteins are localized in the PNC to primarily process RNA polymerase II.
RNA recognition motif, RNP-1 is a putative RNA-binding domain of about 90 amino acids that are known to bind single-stranded RNAs. It was found in many eukaryotic proteins. [ 1 ] [ 2 ] [ 3 ]
20218 Ensembl ENSG00000121774 ENSMUSG00000028790 UniProt Q07666 Q60749 RefSeq (mRNA) NM_001271878 NM_006559 NM_011317 RefSeq (protein) NP_001258807 NP_006550 NP_035447 Location (UCSC) Chr 1: 32.01 – 32.06 Mb Chr 4: 129.6 – 129.64 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse KH domain-containing, RNA-binding, signal transduction-associated protein 1 is a protein that in humans ...
Polypyrimidine tract-binding protein 1 is a protein that in humans is encoded by the PTBP1 gene. [5] [6] [7] This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA).
3181 53379 Ensembl ENSG00000122566 ENSMUSG00000004980 UniProt P22626 O88569 RefSeq (mRNA) NM_002137 NM_031243 NM_016806 NM_182650 RefSeq (protein) NP_002128 NP_112533 NP_058086 NP_872591 NP_001361674 Location (UCSC) Chr 7: 26.17 – 26.2 Mb Chr 6: 51.46 – 51.47 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Heterogeneous nuclear ribonucleoproteins A2/B1 is a protein that in humans ...
The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs in the N-terminal domain which are pivotal for RNA specificity and binding. The protein also has a glycine rich arginine-glycine-glycine (RGG) region called the RGG box which enables protein and RNA binding. It affects many critical genes that are ...