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Fused tetanus is when there is no relaxation of the muscle fibers between stimuli and it occurs during a high rate of stimulation. [5] A fused tetanic contraction is the strongest single-unit twitch in contraction. [6] When tetanized, the contracting tension in the muscle remains constant in a steady state. This is the maximal possible ...
Anti-tetanus immunoglobulin, also known as tetanus immune globulin (TIG) and tetanus antitoxin, is a medication made up of antibodies against the tetanus toxin. [1] It is used to prevent tetanus in those who have a wound that is at high risk, have not been fully vaccinated with tetanus toxoid , or have HIV/AIDS .
Tetanus immunoglobulin (TIG), [1] also called tetanus antibodies or tetanus antitoxin. [46] It can be given as intravenous therapy or by intramuscular injection. Antibiotic therapy to reduce toxin production. Metronidazole intravenous (IV) is a preferred treatment. [48] Benzodiazepines can be used to control muscle spasms.
Immunoglobulin therapy is the use of a mixture of antibodies (normal human immunoglobulin) to treat several health conditions. [13] [14] These conditions include primary immunodeficiency, immune thrombocytopenic purpura, chronic inflammatory demyelinating polyneuropathy, Kawasaki disease, certain cases of HIV/AIDS and measles, Guillain–Barré syndrome, and certain other infections when a ...
[6] [1] Tetanospasmin ("tetanus toxin") is a potent toxin with an estimated lethal dose less than 2.5 nanograms per kilogram of body weight, and is responsible for the symptoms of tetanus. [6] [1] Tetanospasmin spreads via the lymphatic system and bloodstream throughout the body, where it is taken up into various parts of the nervous system. [6]
Diphtheria and tetanus toxoids and whole-cell [10] pertussis (DTP; now also "DTwP" to differentiate from the broader class of triple-combination vaccines) [9] vaccination was licensed in 1949. [13] Since the introduction of the combination vaccine, there has been an extensive decline in the incidence of pertussis, or whooping cough, the disease ...
Tetanus vaccine, also known as tetanus toxoid (TT), is a toxoid vaccine used to prevent tetanus. [2] During childhood, five doses are recommended, with a sixth given during adolescence. [2] After three doses, almost everyone is initially immune, [2] but additional doses every ten years are recommended to maintain immunity. [3]
Post-exposure prophylaxis, also known as post-exposure prevention (PEP), is any preventive medical treatment started after exposure to a pathogen in order to prevent the infection from occurring. It should be contrasted with pre-exposure prophylaxis , which is used before the patient has been exposed to the infective agent.