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For patients with more than 1,000 PVCs per day, the risk of developing left ventricular systolic dysfunction after 5 years follow-up is low. Frequent PVCs may increase the risk of developing cardiomyopathy, which can greatly impair heart function. A PVC burden greater than 10% is the minimal threshold for development of PVC-induced cardiomyopathy.
Ectopic beat is a disturbance of the cardiac rhythm frequently related to the electrical conduction system of the heart, in which beats arise from fibers or group of fibers outside the region in the heart muscle ordinarily responsible for impulse formation (i.e., the sinoatrial node).
The hepatotoxicity of vinyl chloride has long been established since the 1930s when the PVC industry was just in its early stages. In the very first study about the dangers of vinyl chloride, published by Patty in 1930, it was disclosed that exposure of test animals to just a single short-term high dose of vinyl chloride caused liver damage. [31]
A study in the journal Chemosphere in December concluded that toxic brominated flame retardants and organophosphate flame retardants might be present at dangerous levels in some products ...
In a fire, PVC can form hydrogen chloride fumes; the chlorine serves to scavenge free radicals, making PVC-coated wires fire retardant. While hydrogen chloride fumes can also pose a health hazard in their own right, it dissolves in moisture and breaks down onto surfaces, particularly in areas where the air is cool enough to breathe, so would ...
Bigeminy is a cardiac arrhythmia in which there is a single ectopic beat, or irregular heartbeat, following each regular heartbeat.Most often this is due to ectopic beats occurring so frequently that there is one after each sinus beat, or normal heartbeat.
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PCBs were also commonly used as heat stabilizer in cables and electronic components to enhance the heat and fire resistance of PVC. [ 96 ] In the 1930s, the toxicity associated with PCBs and other chlorinated hydrocarbons, including polychlorinated naphthalenes , was recognized because of a variety of industrial incidents. [ 97 ]