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Praziquantel is well absorbed (about 80%) from the gastrointestinal tract. However, due to extensive first-pass metabolism, only a relatively small amount enters systemic circulation. Praziquantel has a serum half-life of 0.8 to 1.5 hours in adults with normal renal and liver function. Metabolites have a half-life of 4 to 5 hours.
Praziquantel eliminates the adult schistosomes but does not kill the eggs and immature worms. [19] Live eggs can be excreted by the infected individuals for weeks after treatment with praziquantel. [19] The immature worms can survive and grow into adult schistosomes after praziquantel therapy. [19]
The prescription drug Praziquantel is usually prescribed in a single dose to patients infected with H.nana. Praziquantel is widely used and preferred due to its high efficacy. Research has shown that the cysticercoid phase of H.nana's life cycle is the most susceptible to the Praziquantel treatment. [2]
Praziquantel is the treatment of choice. [22] Usual treatments are with praziquantel (5–10 mg/kg, single-administration) or niclosamide (adults and children over 6 years: 2 g, single-administration after a light breakfast, followed after 2 hours by a laxative; children aged 2–6 years: 1 g; children under 2 years: 500 mg). [11]
The adult female worm resides within the adult male worm's gynaecophoric canal, which is a modification of the ventral surface of the male, forming a groove. The paired worms move against the flow of blood to their final niche in the mesenteric circulation, where they begin egg production (>32 days).
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This will kill the adult stage but not the cyst or egg stage, so several treatments may be needed. Daily doses of Praziquantel for about one to two weeks' time will be effective against larval cysticercosis in rabbits. One dose of Niclosamide or Praziquantel can be very effective in dogs. [citation needed]