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Modified-release dosage is a mechanism that (in contrast to immediate-release dosage) delivers a drug with a delay after its administration (delayed-release dosage) or for a prolonged period of time (extended-release [ER, XR, XL] dosage) or to a specific target in the body (targeted-release dosage). [1]
A Zydis tablet is produced by lyophilizing or freeze-drying the drug in a matrix usually consisting of gelatin. The resulting product is very lightweight and fragile, and must be dispensed in a special blister pack. Amipara et al., in their article "Oral disintirating tablet of antihypertensive drug" explain the technology's limitations:
The dosage may vary and is titrated to effect, with some guidelines recommending initial treatment with a low dose. [32] Methylphenidate is available in both immediate-release and extended-release (XR) formulations to provide a sustained release of the drug. [33] [34] Methylphenidate is not approved for children under six years of age. [35] [36]
A depot injection, also known as a long-acting injectable (LAI), is a term for an injection formulation of a medication which releases slowly over time to permit less frequent administration of a medication. They are designed to increase medication adherence and consistency, especially in
20 to 30 minutes modified-release dosage tablet containing nicotine polacrilex: Sublingual tablets Blister pack: Over-the-counter Quickly dissolves to releases nicotine through a hard candy Gum: Blister pack: Over-the-counter Chewing the gum releases nicotine as a modified-release dosage: Mouth spray: Mouth spray bottle: Over-the-counter
Risperidone extended-release (Risperisphere) – dopamine D 2 and D 3 receptor antagonist, serotonin 5-HT 1B, 5-HT 2A, 5-HT 2C, and 5-HT 7 receptor antagonist or inverse agonist, α 1 - and α 2-adrenergic receptor antagonist, histamine H 1 receptor inverse agonist, and atypical antipsychotic [91]
Self-microemulsifying drug delivery system; Sink condition; Smoking; Snuff (tobacco) Softgel; Sol–gel process; Solution (chemistry) Subcutaneous administration; Suppository; Suspension (chemistry) Modified-release dosage; Syrup
A 21mg dose Nicoderm CQ patch applied to the left arm Contraceptive patch Clonidine tablets and transdermal patch A transdermal patch which delivers medication is applied to the skin in a medical setting. The patch is labelled with the time and date of administration as well as the administrator's initials. Microneedle patch size comparison [1]