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Logo Expasy 2020. Expasy is an online bioinformatics resource operated by the SIB Swiss Institute of Bioinformatics.It is an extensible and integrative portal which provides access to over 160 databases and software tools and supports a range of life science and clinical research areas, from genomics, proteomics and structural biology, to evolution and phylogeny, systems biology and medical ...
For a protein containing n amino acids, the number of high-energy phosphate bonds required to translate it is 4n-1. [9] The rate of translation varies; it is significantly higher in prokaryotic cells (up to 17–21 amino acid residues per second) than in eukaryotic cells (up to 6–9 amino acid residues per second).
EMBOSS is a free c software analysis package developed for the needs of the molecular biology and bioinformatics user community. [1] The software automatically copes with data in a variety of formats and even allows transparent retrieval of sequence data from the web.
Translation is one of the key energy consumers in cells, hence it is strictly regulated. Numerous mechanisms have evolved that control and regulate translation in eukaryotes as well as prokaryotes. Regulation of translation can impact the global rate of protein synthesis which is closely coupled to the metabolic and proliferative state of a cell.
Smith-Waterman on protein back-translation graph (detects frameshifts at protein level) Protein: Local: M. Gîrdea et al. [24] 2009 PatternHunter: Seeded pattern-matching: Nucleotide: Local: B. Ma et al. [25] [26] 2002–2004 ProbA (also propA) Stochastic partition function sampling via dynamic programming: Both: Global: U. Mückstein: 2002 PyMOL
A translation layer converts user interface controls in the language of a proteomics scientist to underlying complex informatics parameters. [18] Protein Prospector Open source: Protein Prospector is a package of about twenty proteomic analysis tools developed at the University of California San Francisco. The tandem mass spectrometry searching ...
Transfer RNA (tRNA) is an important part of Translation. tRNAs read the mRNA, bringing the amino acids the ribosome assembles into a polypeptide. As such, the abundances and types of tRNAs has a large effect on the speed of protein synthesis. [20] tRNAs can be very similar to other tRNAs, with some tRNA species only differing by a single ...
The strict regulation of translation in both space and time is in part governed by cis-regulatory elements located in 5′ mRNA transcript leaders (TLs) and 3′ untranslated regions (UTRs). Due to their role in translation initiation, mRNA 5′ transcript leaders (TLs) strongly influence protein expression.