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Transglutaminase 2 (TG2) is a ubiquitously expressed (intracellular as well as extracellular) protein, with multiple modes of Post-translational regulation, including an allosteric disulfide bond between Cys-370-Cys-371 that renders the enzyme inactive in the extracellular matrix.
Anti-transglutaminase antibodies are found in celiac disease and may play a role in the small bowel damage in response to dietary gliadin that characterises this condition. [2] In the related condition dermatitis herpetiformis , in which small bowel changes are often found and which responds to dietary exclusion of gliadin-containing wheat ...
Gamma-glutamyltransferase (also γ-glutamyltransferase, GGT, gamma-GT, gamma-glutamyl transpeptidase; [1] EC 2.3.2.2) is a transferase (a type of enzyme) that catalyzes the transfer of gamma-glutamyl functional groups from molecules such as glutathione to an acceptor that may be an amino acid, a peptide or water (forming glutamate).
The endomysium contains a form of transglutaminase called "tissue transglutaminase" or "tTG" for short, and antibodies that bind to this form of transglutaminase are called endomysial autoantibodies (EmA). [6] The antiendomysial antibody test is a histological assay for patient serum binding to esophageal tissue from primate.
Terminal transferases are transferases that can be used to label DNA or to produce plasmid vectors. [101] It accomplishes both of these tasks by adding deoxynucleotides in the form of a template to the downstream end or 3' end of an existing DNA molecule. Terminal transferase is one of the few DNA polymerases that can function without an RNA ...
Big things come in small packages, and this is especially true of the nucleolus.. Made of DNA and RNA proteins, nucleoli are the largest structures in eukaryotic nuclei (the keepers of organisms ...
Business leaders warn of risks from inflationary tariffs and potential budget cuts at Goldman Sachs' Industrial and Materials conference.
Genetic testing, also known as DNA testing, is used to identify changes in DNA sequence or chromosome structure. Genetic testing can also include measuring the results of genetic changes, such as RNA analysis as an output of gene expression , or through biochemical analysis to measure specific protein output. [ 1 ]