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A study investigating the effects of puberty blockers on reproductive health showed no significant difference in the number of irregular menstrual cycles, pregnancies, or pregnancy outcomes between women who received treatment for precocious puberty and those who opted out of treatment. [45]
Overall, puberty blockers have demonstrated an excellent safety and efficacy profile in the treatment of precocious puberty. The most common side effects reported include nonspecific headaches, hot flashes, and implant-related skin reactions. [39]
Although the injection drugs are shown to be safe for children with precocious puberty, they may cause rare side effects like the risk of reactions at the injection site or weakened bones if given ...
A 12-month subcutaneous implant (Supprelin LA) for central precocious puberty (CPP) was approved in May 2007, by the US Food and Drug Administration. Histrelin can be part of the primary care protocol in transgender children/youth, which is an off-label use in the USA [ 5 ] and the UK, [ 6 ] and is used in suppressing cis-sex puberty, until the ...
One red flag to look out for is if precocious puberty occurs too early, such as around 4 or 6 years old. While extremely rare, this should be brought to the attention of your child’s ...
[156] [157] Due to its effects on androgen levels, MPA can produce strong functional antiandrogenic effects, and is used in the treatment of androgen-dependent conditions such as precocious puberty in boys and hypersexuality in men. [158]
Alternatives to bicalutamide in the treatment of male peripheral precocious puberty include spironolactone, cyproterone acetate, and ketoconazole. [148] [149] Bicalutamide with anastrozole is considered to be superior to the combination of spironolactone and testolactone in peripheral precocious puberty, with greater efficacy and fewer side ...
Anastrozole is used at a dosage of 0.5 to 1 mg/day in combination with the antiandrogen bicalutamide in the treatment of peripheral precocious puberty, for instance due to familial male-limited precocious puberty (testotoxicosis) and McCune–Albright syndrome, in boys.