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Narcolepsy is a chronic neurological disorder that impairs the ability to regulate sleep–wake cycles, and specifically impacts REM (rapid eye movement) sleep. [1] The pentad symptoms of narcolepsy include excessive daytime sleepiness (EDS), sleep-related hallucinations, sleep paralysis, disturbed nocturnal sleep (DNS), and cataplexy. [1]
Romance & Cigarettes is a 2005 American musical romantic comedy film written and directed by John Turturro.The film stars an ensemble cast which includes James Gandolfini, Susan Sarandon, Kate Winslet, Steve Buscemi, Bobby Cannavale, Mandy Moore, Mary-Louise Parker, Aida Turturro, Christopher Walken, Barbara Sukowa, Elaine Stritch, Eddie Izzard, and Amy Sedaris.
In Europe, Romance was released mainstream; in the United States, it was reduced to a mainstream-acceptable R rating, and the European original version is unrated.In the United Kingdom, the British Board of Film Classification passed the film uncut for cinemas, though home releases suffered a brief cut to an ejaculation shot.
This condition was first discovered in 1995 by Melberg et al. when they described 5 members of a 4-generation Swedish family where cerebellar ataxia and sensorineural deafness presented as an autosomal dominant trait, 4 of them had narcolepsy and 2 had diabetes mellitus. The oldest members had psychiatric symptoms, neurological anomalies, and ...
Narcolepsy with cataplexy is considered an autoimmune-mediated disorder, so some therapies based on this hypothesis have been developed. Immunological therapies developed include: [ 20 ] Corticosteroids : after testing in 1 human and 1 canine case it proved to be ineffective so is less likely to be further used.
Neurotensin receptor type 1 is a protein that in humans is encoded by the NTSR1 gene. [5] [6] For a crystal structure of NTS1, see pdb code 4GRV.In addition, high-resolution crystal structures have been determined in complex with the peptide full agonist NTS8-13, the non-peptide full agonist SRI-9829, the partial agonist RTI-3a, and the antagonists / inverse agonists SR48692 and SR142948A, as ...
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Thrill of a Romance (also known as Thrill of a New Romance) [2] is an American Technicolor romance film released by Metro-Goldwyn-Mayer in 1945, starring Van Johnson, Esther Williams and Carleton G. Young, with musical performances by Tommy Dorsey & his Orchestra and opera singer Lauritz Melchior.
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