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Spindle cell lipoma is most frequently located in the upper back, shoulder, or posterior neck subcutaneous layer. [3] Nonetheless, reports of it occurring in the mediastinum, hypopharynx, larynx, anterior neck, suprasellar region, esophagus, nasal vestibule, tongue, floor of mouth, vallecula, parotid gland, and breast have been made. [4]
Pleomorphic lipomas, like spindle-cell lipomas, occur for the most part on the backs and necks of elderly men and are characterized by floret giant cells with overlapping nuclei. [7]: 625 Spindle-cell lipomas are asymptomatic, slow-growing, subcutaneous tumors that have a predilection for the posterior back, neck, and shoulders of older men.
Furthermore, multinucleated large cells with radically positioned nuclei in a "floret-like" pattern are strewn among the spindle cells. The histological spectrum is rather diverse, ranging from a tumor that primarily consists of spindle cells with only a few fat cells to a tumor that resembles an average lipoma with few spindle cells ...
Spindle cell sarcoma in muscle tissue. Spindle cell sarcoma is a type of connective tissue cancer.The tumors generally begin in layers of connective tissue, as found under the skin, between muscles, and surrounding organs, and will generally start as a small, inflamed lump, which grows in size.
The undifferentiated component of these tumors most often consists of spindle-shaped cells, with 25% of cases showing cells with an epithelioid cell morphology. These tumors have at least some foci with a histopathology similar to high-grade myxofibrosarcoma type histiocytomas , [ 56 ] [ 58 ] [ 60 ] a tumor formerly termed malignant myxoid ...
The cells have large cytoplasmic lipid droplets interspersed throughout. [4] [5] Myxoid variant: Loose, basophilic matrix, with thick fibrous septa, and foamy histiocytes; Lipoma-like variant: Univacuolated lipocytes, with only isolated hibernoma cells; Spindle cell variant: Spindle cell lipoma combined with hibernoma
Microscopy of tumors in the spindle cell lipoma tentative variant of MFB show a mixture of mature fat cells, ropey collagen, and spindle cells in a myxoid (i.e. background connective tissue that stains blue or purple rather than the red of normal connective tissue) matrix. [18] The blood vessels in these tumors often appear hyalinized. [16]
In neurobiology, spindle cell refers to: Spindle neuron, also known as a von Economo neuron; In general medicine, a spindle cell may refer to the spindle-shaped cells that are found in certain types of tumor: Inflammatory fibroid polyp; Pigmented spindle cell nevus; Spindle cell carcinoma; Spindle cell lipoma; Spindle cell sarcoma
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