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Due to its sympathomimetic effects, pseudoephedrine is a vasoconstrictor and pressor agent (increases blood pressure), a positive chronotrope (increases heart rate), and a positive inotrope (increases force of heart contractions). [18] [1] [22] [19] [20] The influence of pseudoephedrine on blood pressure at clinical doses is controversial.
Phenylephrine, sold under the brand names Neosynephrine and Sudafed PE among others, is a medication used as a decongestant for uncomplicated nasal congestion in the form of a nasal spray or oral tablet, [5] to dilate the pupil, to increase blood pressure given intravenously in cases of low blood pressure, and to relieve hemorrhoids as a suppository.
Pseudoephedrine acts indirectly on the adrenergic receptor system, whereas phenylephrine and oxymetazoline are direct agonists. The effects are not limited to the nose, and these medicines may cause hypertension (high blood pressure) through vasoconstriction; it is for this reason that people with hypertension are advised to avoid them. Most ...
Blood pressure decreases by 10% at the time of sleep onset, and shorter sleep duration can eliminate this drop in blood pressure. Blood pressure was collected during the daytime, and it is ...
The study considered someone as having hypertension if they had a systolic blood pressure of 140 or greater, a diastolic blood pressure of 90 or greater or a history of high blood pressure ...
“Heavy drinking raises blood pressure, increases triglycerides, promotes inflammation and can cause arrhythmias, all of which elevate the risk of heart disease and stroke,” says Routhenstein.
A wide variety of alkaloid and non-alkaloid compounds have been identified in various species of ephedra.Of the six ephedrine-type ingredients found in ephedra (at concentrations of 0.02-3.4%), the most common are ephedrine and pseudoephedrine, [12] which are the sources of its stimulant and thermogenic effects. [3]
Instead, extremely high levels of the precursor hormone corticosterone are produced, some of which is converted to 11-Deoxycorticosterone (DOC), a potent mineralocorticoid not normally clinically important in humans. DOC has blood-pressure raising effects similar to aldosterone, and abnormally high levels result in hypokalemic hypertension. [39]