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In men with prostate cancer, the ratio of free (unbound) PSA to total PSA is decreased. The risk of cancer increases if the free to total ratio is less than 25%. (See graph) The lower the ratio is, the greater the probability of prostate cancer. Measuring the ratio of free to total PSA appears to be particularly promising for eliminating ...
The 4Kscore combines total, free and intact PSA together with human kallikrein 2. [46] It is used to try to determine the risk of a Gleason score greater than 6. [46] The Prostate Health Index (PHI) is a PSA-based blood test for early prostate cancer screening. It may be used to determine when a biopsy is needed.
Those with elevated PSA may undergo secondary screening blood tests that measure subtypes of PSA and other molecules to better predict the likelihood that a person will develop aggressive prostate cancer. Many measure "free PSA" – the fraction of PSA unbound to other blood proteins, usually around 10% to 30%.
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Progression-free survival (PFS) is "the length of time during and after the treatment of a disease, such as cancer, that a patient lives with the disease but it does not get worse". [1] In oncology , PFS usually refers to situations in which a tumor is present, as demonstrated by laboratory testing, radiologic testing, or clinically.
High nucleus/cytoplasm ratio [1] "salt and pepper" chromatin [1] Nuclear molding [1] Necrosis of single cells, or geographic [1] Smearing artifacts [1] Half of cases have usual acinar components [1] Mucinous adenocarcinoma 0.2% [12] ≥25% of tumor shows extracellular mucin [1] Intraluminal mucinous material does not qualify [1] No ...
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For a good test in a population, the post-test probability will be meaningfully higher or lower than the pretest probability. A high likelihood ratio indicates a good test for a population, and a likelihood ratio close to one indicates that a test may not be appropriate for a population.
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