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Gastrointestinal disturbances (including mouth ulcers, indigestion, diarrhea, constipation, etc.) Infections (including sinusitis, the flu, sepsis, UTIs, etc.)
Ribavirin's amide group can make the native nucleoside drug resemble adenosine or guanosine, depending on its rotation. For this reason, when ribavirin is incorporated into RNA, as a base analog of either adenine or guanine, it pairs equally well with either uracil or cytosine , inducing mutations in RNA-dependent replication in RNA viruses.
Early and intravenous ribavirin treatment is required for maximal efficacy, and it can produce considerable side effects. [27] Ribavirin has not been evaluated yet in controlled clinical trials. [citation needed] Use of ribavirin during pregnancy is generally not recommended, as some studies indicate the possibility of teratogenic effects. If ...
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Waxing is commonly used in larger areas and temporarily removes hair for about 2 to 6 weeks. Waxing can cause skin irritation, scars, folliculitis, and thermal injury due to the hot wax, and repeated waxing can reduce hair regrowth over time. [26] Tweezing or plucking hair is best for smaller areas and can remove hair for 2 to 12 weeks. [27]
Taribavirin has better liver-targeting than ribavirin, and has a shorter life in the body due to less penetration and storage in red blood cells. It is expected eventually to be the drug of choice for viral hepatitis syndromes in which ribavirin is active. These include hepatitis C and perhaps also hepatitis B and yellow fever.
For hepatitis C it is typically used together with ribavirin and cure rates are between 24 and 92%. [3] [4] For hepatitis B it may be used alone. [5] It is given by injection under the skin. [3] Side effects are common. [6] They may include headache, feeling tired, depression, trouble sleeping, hair loss, nausea, pain at the site of injection ...
An interesting variation of this idea is the use of genetically modified cells that can produce custom-tailored ribozymes. This is part of a broader effort to create genetically modified cells that can be injected into a host to attack pathogens by generating specialized proteins that block viral replication at various phases of the viral life ...