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Cyclin-dependent kinase 2, also known as cell division protein kinase 2, or Cdk2, is an enzyme that in humans is encoded by the CDK2 gene. [ 5 ] [ 6 ] The protein encoded by this gene is a member of the cyclin-dependent kinase family of Ser/Thr protein kinases .
Cyclin E/Cdk2 activity levels throughout the cell cycle. The Cyclin E/Cdk2 complex is a structure composed of two proteins, cyclin E and cyclin-dependent kinase 2 (Cdk2). ). Similar to other cyclin/Cdk complexes, the cyclin E/Cdk2 dimer plays a crucial role in regulating the cell cycle, with this specific complex peaking in activity during the G1/S transit
Without cyclin, CDK is less active than in the cyclin-CDK heterodimer complex. [ 5 ] [ 6 ] CDKs phosphorylate proteins on serine (S) or threonine (T) residues. The specificity of CDKs for their substrates is defined by the S/T-P-X-K/R sequence, where S/T is the phosphorylation site, P is proline, X is any amino acid, and the sequence ends with ...
In CDK-cyclin complexes, this activation region is composed of a conserved αL-12 Helix and contains a key phosphorylatable residue (usually Threonine for CDK-cyclin partners, but also includes Serine and Tyrosine) that mediates the enzymatic activity of the CDK. It is at this essential residue (T160 in CDK2 complexes, T177 in CDK6 complexes ...
8099 13445 Ensembl ENSG00000111328 ENSMUSG00000029394 UniProt O14519 O35207 RefSeq (mRNA) NM_001270433 NM_001270434 NM_004642 NM_013812 RefSeq (protein) NP_001257362 NP_001257363 NP_004633 NP_038840 Location (UCSC) Chr 12: 123.25 – 123.27 Mb Chr 5: 124.48 – 124.5 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cyclin-dependent kinase 2-associated protein 1 is an enzyme that in ...
CIP/KIP family proteins bind a wide range of G1/S and S-phase cyclin-CDK complexes including cyclin D-CDK4,6 and cyclin E-, A-CDK2 complexes. Traditionally it was assumed that CIP/KIP proteins played a role in inhibiting all of these complexes; however it was later discovered that CIP/KIP proteins, while inhibiting CDK2 activity, may also activate cyclin D-CDK4,6 activity by facilitating ...
The Weighted Companion Cube, or simply the Companion Cube, is an item featured in the Portal series of video games by Valve Corporation.Initially featured in a single level of the original Portal, Test Chamber 17, as one of Aperture Science's ubiquitous Weighted Storage Cubes with heart symbols printed on the outside, it is given to the game's main character, Chell, as part of the antagonist ...
The Roman physician Galen mapped the four temperaments (sanguine, phlegmatic, choleric and melancholic) to a matrix of hot/cold and dry/wet, taken from the four classical elements. [1] Two of these temperaments, sanguine and choleric, shared a common trait: quickness of response (corresponding to "heat"), while the melancholic and phlegmatic ...