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Fluoxetine increases the concentration of circulating allopregnanolone, a potent GABA A receptor positive allosteric modulator, at concentrations that are inactive on serotonin reuptake. [117] [120] Norfluoxetine, a primary active metabolite of fluoxetine, produces a similar effect on allopregnanolone levels in the brains of mice. [117]
Fluoxetine (Prozac) was similar to sertraline when it came to this side effect. Researchers also estimated that escitalopram, paroxetine, and duloxetine each had an associated 10-15% higher risk ...
A 2009 Advisory Committee to the U.S. Food and Drug Administration found that online anecdotal reports of discontinuation syndrome related to duloxetine included severe symptoms and exceeded prevalence of both paroxetine and venlafaxine reports by over 250% (although acknowledged this may have been influenced by duloxetine being a much newer ...
Despite their side effects, some tricyclic antidepressants may be effective for improving depression symptoms when other, newer medications aren’t effective. Atypical antidepressants.
A 2021 study linking strawberries to heart health found eating 2.5 servings of strawberries per day for four weeks improved LDL cholesterol levels in adults with obesity and high cholesterol.
Paroxetine may produce discontinuation-related symptoms at a greater rate than other SSRIs, though qualitatively similar effects have been reported for all SSRIs. [181] [182] Discontinuation effects appear to be less for fluoxetine, perhaps owing to its long half-life and the natural tapering effect associated with its slow clearance from the ...
Insulin. Insulin is involved in regulating blood sugar levels. It helps move glucose from blood into cells, where it can be used for energy. This hormone is also partly responsible for storing ...
CYP2D6 inhibitors (e.g., fluoxetine, paroxetine and quinidine) can increase exposure for atomoxetine and it can also increase atomoxetine steady-state plasma concentration. Antihypertensive drugs because it can possibly increase the blood pressure; β2-agonist e.g. albuterol because it may increase the efficacy of albuterol on the ...
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