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The effect of grapefruit juice with regard to drug absorption was originally discovered in 1989 by a group led by pharmacologist David Bailey. Their first published clinical report on grapefruit drug interactions was in 1991. [9] The effect was first discovered accidentally in 1989, when a test of drug interactions with alcohol used grapefruit ...
In addition, grapefruit can have the opposite effect on certain antihistamines, such as Allegra. These allergy medicines are absorbed into our body's cells through proteins known as transporters ...
The effect of grapefruit juice with regard to drug absorption was originally discovered in 1989. The first published report on grapefruit drug interactions was in 1991 in the Lancet entitled "Interactions of Citrus Juices with Felodipine and Nifedipine", and was the first reported food-drug interaction clinically. The effects of grapefruit last ...
Drug interaction. Grapefruit juice can act as an enzyme inhibitor, affecting the metabolism of drugs. In pharmaceutical sciences, drug interactions occur when a drug's mechanism of action is affected by the concomitant administration of substances such as foods, beverages, or other drugs. A popular example of drug–food interaction is the ...
They can sometimes have unintended interactions with prescription and over-the-counter medications. Skip to main content. 24/7 Help. For premium support please call: 800-290-4726 ...
Grapefruit and grapefruit juice have been found to interact with numerous drugs, in many cases resulting in adverse effects. [4] This happens in two ways: one is that grapefruit can block an enzyme which metabolizes medication, [5] and if the drug is not metabolized, then the level of the drug in the blood can become too high, leading to an adverse effect. [5]
Ciprofloxacin is a broad-spectrum antibiotic of the fluoroquinolone class. It is active against some Gram-positive and many Gram-negative bacteria. [79] It functions by inhibiting a type II topoisomerase (DNA gyrase) and topoisomerase IV, [80][81] necessary to separate bacterial DNA, thereby inhibiting cell division.
A single glass of grapefruit juice can interfere with your body's ability to break down a medication. Here's how to protect your health. Grapefruit can interfere with certain medications