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Space-filling model of the PTEN protein (blue) complexed with tartaric acid (brown) [5] Phosphatase and tensin homolog (PTEN) is a phosphatase in humans and is encoded by the PTEN gene. [6] Mutations of this gene are a step in the development of many cancers, specifically glioblastoma, lung cancer, breast cancer, and prostate cancer.
PTEN also refers to a member of the class, phosphatase and tensin homolog. [citation needed] This enzyme participates in 10 metabolic pathways: inositol phosphate metabolism, phosphatidylinositol signaling system, p53 signaling pathway, focal adhesion, tight junction, endometrial cancer, glioma, prostate cancer, melanoma, and small cell lung ...
The PI3K/AKT pathway has a natural inhibitor called Phosphatase and tensin homolog whose function is to limit proliferation in cells, helping to prevent cancer. Knocking out PTEN has been shown to increase the mass of the brain because of the unregulated proliferation that occurs. [3] PTEN works by dephosphorylating PIP3 to PIP2 which limits ...
11191 n/a Ensembl ENSG00000237984 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 9: 33.67 – 33.68 Mb n/a PubMed search n/a Wikidata View/Edit Human Phosphatase and tensin homolog (mutated in multiple advanced cancers 1), pseudogene 1, also known as PTENP1, is a human pseudogene. which has a partial reactivated function as a competing endogenous RNA ...
The PTP domain is unlikely to be active in tensin 1, owing to mutation of the essential nucleophilic cysteine in the signature motif to asparagine. [5] Nevertheless, phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase, the well-studied tumor suppressor that is better known as PTEN, gets its name from homology with PTPs and tensin 1. [6]
Phosphatase and tensin homolog (PTEN) antagonises PI3K by converting PI(3,4,5)P 3 into PI(4,5)P 2. Loss of PTEN function leads to over-activation of Akt and is common in cancer cells (PTEN is a tumour suppressor). SH2-containing Inositol Phosphatase (SHIP) also dephosphorylates PI(3,4,5)P 3, at the 5' position of the inositol ring. [22]
Phosphatase and tensin homolog is originally identified as a tumor suppressor gene. [9] Recent studies found that Pten also suppressed axon regeneration in retinal ganglion cells, corticospinal tract, and DRG neurons. [10] [11] [12] So far 3 Pten isoforms (Pten, PtenJ1, and Pten J2) have been identified and analyzed. Pten J1 is identical in ...
PtdIns(3,4,5)P 3 is dephosphorylated by the phosphatase PTEN on the 3 position, generating PI(4,5)P 2, and by SHIPs (SH2-containing inositol phosphatase) on the 5' position of the inositol ring, producing PI(3,4)P 2. [5] The PH domain in a number of proteins binds to PtdIns(3,4,5)P 3. Such proteins include Akt/PKB, [6] PDPK1, [7] Btk1, and ARNO ...