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The spleen is made of red pulp and white pulp, separated by the marginal zone; 76–79% of a normal spleen is red pulp. [4] Unlike white pulp, which mainly contains lymphocytes such as T cells, red pulp is made up of several different types of blood cells, including platelets, granulocytes, red blood cells, and plasma. [1] The red pulp also ...
White pulp is a histological designation for regions of the spleen (named because it appears whiter than the surrounding red pulp on cross section), that encompasses approximately 25% of splenic tissue. White pulp consists entirely of lymphoid tissue. Specifically, the white pulp encompasses several areas with distinct functions:
Micrograph of splenic tissue showing the red pulp (red), white pulp (blue nuclei in lighter background) and a thickened inflamed capsule (mostly pink – top of image). H&E stain. The spleen contains two different tissues, white pulp (A) and red pulp (B). The white pulp functions in producing and growing immune and blood cells.
The cords of Billroth (also known as splenic cords or red pulp cords) are found in the red pulp of the spleen between the sinusoids, consisting of fibrils and connective tissue cells with a large population of monocytes and macrophages.
Patients who have a hemoglobin level of less than 12 g/dL, a lactate dehydrogenase level higher than normal, and/or a blood serum albumin levels of less than 3.5 g/dL are likely to have more an aggressive disease course and a shorter survival. [12] However, even high-risk patients have even odds of living for five years after diagnosis. [12]
The marginal zone is the region at the interface between the non-lymphoid red pulp and the lymphoid white-pulp of the spleen. (Some sources consider it to be the part of red pulp which borders on the white pulp, while other sources consider it to be neither red pulp nor white pulp.) A marginal zone also exists in the lymphoid follicles of lymph ...
Splenic marginal zone lymphoma (SMZL) (also known as well-differentiated lymphocytic lymphoma, small lymphocytic lymphoma, and splenic lymphoma with circulating villous lymphocytes) is a lymphoma made up of small B-cells that replace the normal architecture of the white pulp of the spleen.
The mucosa-associated lymphoid tissue (MALT), also called mucosa-associated lymphatic tissue, is a diffuse system of small concentrations of lymphoid tissue found in various submucosal membrane sites of the body, such as the gastrointestinal tract, nasopharynx, thyroid, breast, lung, salivary glands, eye, and skin.