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Metabolife International, Inc. was a multi-level marketing company based in San Diego, California which manufactured dietary supplements.Metabolife's best-selling product, an ephedra supplement called Metabolife 356, once generated hundreds of millions of dollars in annual sales. [1]
A wide variety of alkaloid and non-alkaloid compounds have been identified in various species of Ephedra.Of the six ephedrine-type ingredients found in ephedra (at concentrations of 0.02-3.4%), the most common are ephedrine and pseudoephedrine, [13] which are the sources of its stimulant and thermogenic effects. [4]
Chemins was the manufacturer of dietary supplements for the multi-level marketing companies Metabolife (i.e., Metabolife 356, an ephedra-based supplement that was withdrawn following numerous adverse event reports) [4] [5] and LifeVantage (i.e., Protandim, an herbal-based supplement). [6] Chemins' assets were acquired by Nexgen Pharma in 2007. [7]
Ephedra is a genus of gymnosperm shrubs.As of February 2025 there were 77 recognized species. The various species of Ephedra are widespread in many arid regions of the world, ranging across southwestern North America, southern Europe, northern Africa, southwest and central Asia, northern China, and western South America. [2]
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In biochemistry, a metabolite is an intermediate or end product of metabolism. [1] The term is usually used for small molecules.Metabolites have various functions, including fuel, structure, signaling, stimulatory and inhibitory effects on enzymes, catalytic activity of their own (usually as a cofactor to an enzyme), defense, and interactions with other organisms (e.g. pigments, odorants, and ...
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