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BRAF is a human gene that encodes a protein called B-Raf. The gene is also referred to as proto-oncogene B-Raf and v-Raf murine sarcoma viral oncogene homolog B , while the protein is more formally known as serine/threonine-protein kinase B-Raf .
V600E is a mutation of the BRAF gene in which valine (V) is substituted by glutamic acid (E) at amino acid 600. [1] [2] It is a driver mutation in a proportion of certain diagnoses, including melanoma, [3] [4] hairy cell leukemia, [5] [6] papillary thyroid carcinoma, [7] [8] colorectal cancer, [9] non-small-cell lung cancer, [10] [11] Langerhans cell histiocytosis, [12] Erdheim–Chester ...
Discoid lupus erythematosus is an uncommon autoimmune disease of the skin in dogs. It does not progress to systemic lupus erythematosus in dogs. The most common initial symptom is scaling and loss of pigment on the nose. [34] Juvenile cellulitis, also known as puppy strangles, is a disease that affects puppies. Its cause is unknown, but it is ...
Dogs that are DEA 1.1 negative are universal donors. Blood from DEA 1.1 positive dogs should never be transfused into DEA 1.1 negative dogs. If it is the dog's first transfusion the red cells transfused will have a shortened life due to the formation of alloantibodies to the cells themselves and the animal will forever be sensitized to DEA 1.1 ...
A dog with degenerative myelopathy often stands with its legs close together and may not correct an unusual foot position due to a lack of conscious proprioception. Canine degenerative myelopathy, also known as chronic degenerative radiculomyelopathy, is an incurable, progressive disease of the canine spinal cord that is similar in many ways to amyotrophic lateral sclerosis (ALS).
Consistent energy around the house: Dogs eating a diet of rice or other carbohydrates have a glucose spike after eating, which leads to "zoomies," whereas dogs on a mostly meat diet have stable ...
This suggests that there is a genetic factor to the disorder. A questionnaire to dog owners and a blood sample of 181 dogs from four breeds, miniature and standard bull terriers, German shepherds, and Staffordshire bull terriers showed these to be more susceptible to compulsive and repetitive behaviors. [19]
Skin conditions in dogs are very common, so it's important to recognize the symptoms and understand the factors that cause them. Dr. Rebecca MacMillan, a vet with over 15 years of experience, says ...