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In Windows 8 and 8.1, the ability to change the desktop wallpaper is still possible, however changing the Start screen color & design and lock screen wallpaper are disabled. Notifications also appear occasionally telling the user to activate. However, the operating system otherwise functions normally. [19]
Product activation is a license validation procedure required by some proprietary software programs. Product activation prevents unlimited free use of copied or replicated software. Unactivated software refuses to fully function until it determines whether it is authorized to fully function. Activation allows the software to stop blocking its use.
The activation function of a node in an artificial neural network is a function that calculates the output of the node based on its individual inputs and their weights. Nontrivial problems can be solved using only a few nodes if the activation function is nonlinear .
A transcriptional activator is a protein (transcription factor) that increases transcription of a gene or set of genes. [1] Activators are considered to have positive control over gene expression, as they function to promote gene transcription and, in some cases, are required for the transcription of genes to occur.
The reaction it catalyzes is: pyruvate + HCO − 3 + ATP → oxaloacetate + ADP + P. It is an important anaplerotic reaction that creates oxaloacetate from pyruvate. PC contains a biotin prosthetic group [1] and is typically localized to the mitochondria in eukaryotes with exceptions to some fungal species such as Aspergillus nidulans which have a cytosolic PC.
Leonard P. Guarente is recognized as the leading proponent of the hypothesis that caloric restriction slows aging by activation of Sirtuins. [citation needed]STACs have been discovered by Konrad Howitz of Biomol Inc and biologist David Sinclair.
It is an isozyme of hexokinase and is found mainly in pancreatic β cells, but also liver, gut, and brain cells where glycolysis cause glucose-induced insulin secretion. [2] Glucokinase activator lowers blood glucose concentrations by enhancing glucose uptake in the liver and increasing insulin production by the pancreatic β cells. [2]
Peroxisome proliferator-activated receptor gamma (PPAR-γ or PPARG), also known as the glitazone reverse insulin resistance receptor, or NR1C3 (nuclear receptor subfamily 1, group C, member 3) is a type II nuclear receptor functioning as a transcription factor that in humans is encoded by the PPARG gene. [5] [6] [7]