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Thromboplastin (TPL) is derived from cell membranes and is a mixture of both phospholipids and tissue factor, neither of which are enzymes. Thromboplastin acts on and accelerates the activity of Factor Xa, also known as thrombokinase, [ 1 ] aiding blood coagulation through catalyzing the conversion of prothrombin to thrombin .
2152 14066 Ensembl ENSG00000117525 ENSMUSG00000028128 UniProt P13726 P20352 RefSeq (mRNA) NM_001993 NM_001178096 NM_010171 RefSeq (protein) NP_001171567 NP_001984 NP_034301 Location (UCSC) Chr 1: 94.53 – 94.54 Mb Chr 3: 121.52 – 121.53 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Tissue factor, also called platelet tissue factor or Coagulation factor III, is a protein present ...
Factor XI (FXI) is produced by the liver and circulates as a homo-dimer in its inactive form. [9] The plasma half-life of FXI is approximately 52 hours. The zymogen factor is activated into factor XIa by factor XIIa (FXIIa), thrombin, and FXIa itself; due to its activation by FXIIa, FXI is a member of the "contact pathway" (which includes HMWK, prekallikrein, factor XII, factor XI, and factor IX).
Liver function tests (LFTs or LFs), also referred to as a hepatic panel or liver panel, are groups of blood tests that provide information about the state of a patient's liver. [1] These tests include prothrombin time (PT/INR), activated partial thromboplastin time (aPTT), albumin , bilirubin (direct and indirect), and others.
2147 14061 Ensembl ENSG00000180210 ENSMUSG00000027249 UniProt P00734 P19221 RefSeq (mRNA) NM_000506 NM_001311257 NM_010168 RefSeq (protein) NP_000497 NP_034298 Location (UCSC) Chr 11: 46.72 – 46.74 Mb Chr 2: 91.46 – 91.47 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Role of thrombin in the blood coagulation cascade Prothrombin (coagulation factor II) is encoded in the human by ...
Fresh normal plasma has all the blood coagulation factors with normal levels. If the problem is a simple factor deficiency, mixing the patient plasma 1:1 with plasma that contains 100% of the normal factor level results in a level ≥50% in the mixture (say the patient has an activity of 0%; the average of 100% + 0% = 50%). [3]
The partial thromboplastin time (PTT), also known as the activated partial thromboplastin time (aPTT or APTT), is a blood test that characterizes coagulation of the blood. A historical name for this measure is the Kaolin-cephalin clotting time ( KCCT ), [ 1 ] reflecting kaolin and cephalin as materials historically used in the test.
2161 58992 Ensembl ENSG00000131187 ENSMUSG00000021492 UniProt P00748 Q80YC5 RefSeq (mRNA) NM_000505 NM_021489 RefSeq (protein) NP_000496 NP_067464 Location (UCSC) Chr 5: 177.4 – 177.42 Mb Chr 13: 55.57 – 55.57 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Coagulation factor XII, also known as Hageman factor, is a plasma protein involved in coagulation. It is the zymogen form of ...