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  2. Cyclin D1 - Wikipedia

    en.wikipedia.org/wiki/Cyclin_D1

    Cyclin D1 was originally cloned as a breakpoint rearrangement in parathyroid adenoma [5] and was shown to be required for progression through the G1 phase of the cell cycle to induce cell migration, [14] angiogenesis [15] and to induce the Warburg effect. [16] Cyclin D1 is a protein required for progression through the G1 phase of the cell ...

  3. Allograft inflammatory factor 1 - Wikipedia

    en.wikipedia.org/wiki/Allograft_inflammatory...

    Upregulation of AIF-1 enhanced activity of NF-ΚB and increased expression of cyclin D1. Cyclin D1 contribute to cell proliferation and mutation in this gene has been connected with variety of tumors. It has also been shown that AIF-1 expression can contribute to progression of cancer by inhibition of apoptosis in cells. [21] [22]

  4. In situ lymphoid neoplasia - Wikipedia

    en.wikipedia.org/wiki/In_situ_lymphoid_neoplasia

    The cyclin D1-expressing lymphocytes generally populate the inner layers of the marginal zone but on occasion some of these cells may be identified in the germinal centers surrounded by these marginal zones as well as in the bone marrow. The cells do not disrupt the overall architecture of the involved follicles.

  5. List of histologic stains that aid in diagnosis of cutaneous ...

    en.wikipedia.org/wiki/List_of_histologic_stains...

    Positive histologic stains that aid in the diagnosis of conditions of or affecting the human integumentary system Stain Cell, material, and/or structure(s) stained

  6. Cyclin D - Wikipedia

    en.wikipedia.org/wiki/Cyclin_D

    Cyclin D is a member of the cyclin protein family that is involved in regulating cell cycle progression. The synthesis of cyclin D is initiated during G1 and drives the G1/S phase transition. Cyclin D protein is anywhere from 155 (in zebra mussel) to 477 (in Drosophila) amino acids in length. [2]

  7. Mesoblastic nephroma - Wikipedia

    en.wikipedia.org/wiki/Mesoblastic_nephroma

    The histology, association with the ETV6-NRTK3 fusion gene along with certain chromosome trisomies, and the distribution of markers for cell type (i.e. cyclin D1 and Beta-catenin) within this tumor are the same as those found in cellular mesoblastic nephroma. Mesoblastic nephroma and congenital infantile sarcoma appear to be the same diseases ...

  8. Monoclonal B-cell lymphocytosis - Wikipedia

    en.wikipedia.org/wiki/Monoclonal_B-cell_lymphocy...

    Mantle cell lymphoma: The monoclonal B-cells in this aggressive lymphoma are CD5+ in most cases, CD10−, CD23−, CD43+, CD103−, complete Ig+, and express cyclin D1; these cells have translocations between chromosomes 11 and 14 in >95% of cases and in many cases overexpress the SOX11 transcription factor gene. [2]

  9. p16 - Wikipedia

    en.wikipedia.org/wiki/P16

    p16 is an inhibitor of cyclin-dependent kinases (CDK). It slows down the cell cycle by prohibiting progression from G1 phase to S phase. Otherwise, CDK4/6 binds cyclin D and forms an active protein complex that phosphorylates retinoblastoma protein (pRB). Once phosphorylated, pRB dissociates from the transcription factor E2F1. This liberates ...