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Mucociliary clearance (MCC), mucociliary transport, or the mucociliary escalator describes the self-clearing mechanism of the airways in the respiratory system. [1] It is one of the two protective processes for the lungs in removing inhaled particles including pathogens before they can reach the delicate tissue of the lungs.
SEM image of syncytial virions taken from A549 cells in the lung epithelium. Following injury to airway epithelium, the basal cells can become infected by the respiratory syncytial virus . When this happens the basal cell can be skewed to favour the differentiation of mucus-producing (secretory goblet cells ) over that of ciliated cells.
The cells in the respiratory epithelium are of five main types: a) ciliated cells, b) goblet cells, c) brush cells, d) airway basal cells, and e) small granule cells (NDES) [6] Goblet cells become increasingly fewer further down the respiratory tree until they are absent in the terminal bronchioles; club cells take over their role to some extent here. [7]
Ectodermal tissue from the anterior head region invaginates posteriorly to form olfactory pits, which fuse with endodermal tissue of the developing pharynx. An olfactory pit is one of a pair of structures that will enlarge to become the nasal cavity. At about this same time, the lung bud forms.
In the airways—the trachea, bronchi, and bronchioles—the lining of mucus is produced by specialized airway epithelial cells called goblet cells, and submucosal glands. Small particles such as dust, particulate pollutants , and allergens , as well as infectious agents and bacteria are caught in the viscous nasal or airway mucus and prevented ...
Also called compression-rupture lacerations, type 1 are the most common type and usually occur in a central location of the lung. [1] They tend to be large, ranging in size from 2–8 cm. [ 19 ] The shearing stress in type 2 results when the lower chest is suddenly compressed and the lower lung is suddenly moved across the vertebral bodies.
Congenital pulmonary airway malformation (CPAM), formerly known as congenital cystic adenomatoid malformation (CCAM), is a congenital disorder of the lung similar to bronchopulmonary sequestration. In CPAM, usually an entire lobe of lung is replaced by a non-working cystic piece of abnormal lung tissue.
Repair of extensive tears can include sewing a flap of tissue taken from the membranes surrounding the heart or lungs (the pericardium and pleura, respectively) over the sutures to protect them. [2] When lung tissue is destroyed as a result of TBI complications, pneumonectomy or lobectomy (removal of a lung or of one lobe, respectively) may be ...