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Menotropin preparations are designed for use in selected women where they stimulate the ovaries to mature follicles, thus making them more fertile. They are administered by typically daily injection, intramuscularly or subcutaneously, for about ten days under close supervision to adjust dose and duration of therapy.
In another, higher-dose study, SHBG levels were lower by 59% in a group of women treated with 50 mg/day oral MPA alone relative to an untreated control group of women. [180] In massive-dose studies of oral or injectable MPA (e.g., 500–1,000 mg/day), the medication decreased SHBG levels by about 80%. [182] [183] [184]
In men: Used to treat select cases of Hypogonadotropic Hypogonadism in adult males. [25] In off-label use, some urologists prescribe hCG in low doses in combination with testosterone replacement to preserve fertility. [26] In male children: Also used to treat prepubertal cryptorchidism not due to anatomical obstruction.
25–50 mg 1x/4–6 weeks Mixed testosterone esters: Climacteron a: Oil solution: 150 mg 1x/4–8 weeks Omnadren, Sustanon: Oil solution: 50–100 mg 1x/4–6 weeks Nandrolone decanoate: Deca-Durabolin: Oil solution: 25–50 mg 1x/6–12 weeks Prasterone enanthate a: Gynodian Depot: Oil solution: 200 mg 1x/4–6 weeks Implant: Testosterone ...
In transgender women, estradiol valerate given by intramuscular injection is usually used at a dosage of 5 to 20 mg, but up to 30 to 40 mg, once every 2 weeks. [30] [31] [29] Estradiol valerate has also been used at a dose of 10 to 40 mg by intramuscular injection to limit bleeding in women with hemorrhage due to dysfunctional uterine bleeding.
Clinical studies have shown that the most common side effect is a slight reaction at the site of injection in the form of redness, and sometimes swelling. [4] Clinical studies have shown that, one hour after injection, the incidence of at least one moderate or severe local skin reaction per treatment cycle was 12% in 4 patients treated with ganirelix and 25% in patients treated subcutaneously ...
In comparison with the smaller dose, finasteride 5mg had a few additional prominent side effects, and a slightly higher severity of the side effects seen in the 1mg dose.
[8] [9] In men, they are being investigated in the treatment of benign prostatic hyperplasia [10] and also as potential contraceptive agents. [11] GnRH antagonists could be used as puberty blockers in transgender youth and to suppress sex hormone levels in transgender adolescents and adults, but have not been studied in this context.