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The Akt signaling pathway or PI3K-Akt signaling pathway is a signal transduction pathway that promotes survival and growth in response to extracellular signals. Key proteins involved are PI3K ( phosphatidylinositol 3-kinase ) and Akt ( protein kinase B ).
Once correctly positioned at the membrane via binding of PIP3, Akt can then be phosphorylated by its activating kinases, phosphoinositide-dependent kinase-1 (PDPK1 at threonine 308 in Akt1 and threonine 309 in Akt2) and the mammalian target of rapamycin complex 2 (mTORC2 at serine 473 (Akt1) and 474 (Akt2)) which is found at high levels in the ...
The transforming cellular sequences, v-akt, were cloned from a transformed mink cell clone and these sequences were used to identify Akt1 and Akt2 in a human clone library. AKT8 was isolated by Stephen Staal in the laboratory of Wallace P. Rowe; he subsequently cloned v-akt and human AKT1 and AKT2 while on staff at the Johns Hopkins Oncology ...
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This gene is a putative oncogene encoding a protein belonging to the AKT subfamily of serine/threonine kinases that contain SH2-like (Src homology 2-like) domains.The encoded protein is a general protein kinase capable of phosphorylating several known proteins.
A fan film is a film or video inspired by a movie, television show, comic book or a similar source, created by fans rather than by the source's copyright holders or creators. See also: Category:Documentary films about fandom
The Organization for Transformative Works offers the following services and platforms to fans in a myriad of fandoms: . Archive of Our Own (AO3): An open-source, non-commercial, non-profit, multi-fandom web archive built by fans for hosting fan fiction and for embedding other fanwork, including fan art, fan videos, and podfic.
Fanvids are created based on material from TV shows, movies, and occasionally official music videos to make an argument through juxtaposing the original video with song lyrics. In vids, the music is an analytic device rather than a soundtrack. [ 2 ]