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The development of the nervous system in humans, or neural development, or neurodevelopment involves the studies of embryology, developmental biology, and neuroscience.These describe the cellular and molecular mechanisms by which the complex nervous system forms in humans, develops during prenatal development, and continues to develop postnatally.
The vertebrate central nervous system (CNS) is derived from the ectoderm—the outermost germ layer of the embryo. A part of the dorsal ectoderm becomes specified to neural ectoderm – neuroectoderm that forms the neural plate along the dorsal side of the embryo.
Formation of the neuroectoderm is the first step in the development of the nervous system. [1] The neuroectoderm receives bone morphogenetic protein-inhibiting signals from proteins such as noggin, which leads to the development of the nervous system from this tissue. Histologically, these cells are classified as pseudostratified columnar cells.
All of the organs that rise from the ectoderm such as the nervous system, teeth, hair and many exocrine glands, originate from two adjacent tissue layers: the epithelium and the mesenchyme. [8] Several signals mediate the organogenesis of the ectoderm such as: FGF, TGFβ, Wnt, and regulators from the hedgehog family.
In embryology, the neural plate is a key developmental structure that serves as the basis for the nervous system. Cranial to the primitive node of the embryonic primitive streak, ectodermal tissue thickens and flattens to become the neural plate. The region anterior to the primitive node can be generally referred to as the neural plate.
The neural plate folds in upon itself to form the neural tube, which will later differentiate into the spinal cord and the brain, eventually forming the central nervous system. [2] Computer simulations found that cell wedging and differential proliferation are sufficient for mammalian neurulation. [3]
In the developing chordate (including vertebrates), the neural tube is the embryonic precursor to the central nervous system, which is made up of the brain and spinal cord. The neural groove gradually deepens as the neural folds become elevated, and ultimately the folds meet and coalesce in the middle line and convert the groove into the closed ...
Pages in category "Embryology of nervous system" The following 43 pages are in this category, out of 43 total. This list may not reflect recent changes. A.