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XLR-11 (5"-fluoro-UR-144 or 5F-UR-144) is a drug that acts as a potent agonist for the cannabinoid receptors CB 1 and CB 2 with EC 50 values of 98 nM and 83 nM ...
AM-2201 (1-(5-fluoropentyl)-3-(1-naphthoyl)indole) is a recreational designer drug that acts as a potent but nonselective full agonist for the cannabinoid receptor. [3] It is part of the AM series of cannabinoids discovered by Alexandros Makriyannis at Northeastern University .
EAM-2201 (4'-ethyl-AM-2201, 5"-fluoro-JWH-210, SGT-14) is a drug that presumably acts as a potent agonist for the cannabinoid receptors. [2] It had never previously been reported in the scientific or patent literature, and was first identified by laboratories in Japan in July 2012 as an ingredient in synthetic cannabis smoking blends [3] Like the closely related MAM-2201 which had been first ...
Synthetic cannabinoids are a class of designer drug molecules that bind to the same receptors to which cannabinoids (THC, CBD and many others) in cannabis plants attach. [1] These novel psychoactive substances should not be confused with synthetic phytocannabinoids (obtained by chemical synthesis ) or synthetic endocannabinoids from which they ...
AM-694 is an agonist for cannabinoid receptors. It has a K i of 0.08 nM at CB 1 and 18 times selectivity over CB 2 with a K i of 1.44 nM. [ 2 ] It is unclear what is responsible for this unusually high CB 1 binding affinity, but it makes the 18 F radiolabelled derivative of AM-694 useful for mapping the distribution of CB 1 receptors in the body.
AM-679 was one of the first 3-(2-iodobenzoyl)indole derivatives that was found to have significant cannabinoid receptor affinity, and while AM-679 itself has only modest affinity for these receptors, it was subsequently used as a base to develop several more specialised cannabinoid ligands that are now widely used in research, including the ...
AM-2233 is a drug that acts as a highly potent full agonist for the cannabinoid receptors, with a K i of 1.8 nM at CB 1 and 2.2 nM at CB 2 as the active (R) enantiomer. [1] It was developed as a selective radioligand for the cannabinoid receptors and has been used as its 131 I derivative for mapping the distribution of the CB 1 receptor in the brain.
5F-CUMYL-PINACA (also known as SGT-25 and sometimes sold in e-cigarette form as C-Liquid) [1] is an indazole-3-carboxamide based synthetic cannabinoid. [2] 5F-CUMYL-PINACA acts as a potent agonist for the cannabinoid receptors, with the original patent claiming approximately 4x selectivity for CB 1, having an EC 50 of <0.1 nM for human CB 1 receptors and 0.37 nM for human CB 2 receptors. [3]