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Methylprednisolone acetate suspension (Depo-Medrol) is a 6-methyl derivative of prednisolone that melts at 215 degrees Celsius with some decomposition. [23] Methylprednisolone sodium succinate (Solu-Medrol) is the sodium succinate ester of methylprednisolone.
Prednisolone has a relatively short half-life, ranging 2–4 hours. It also has a large therapeutic window, considering the dosage required to produce a therapeutic effect is a few times higher than what the body naturally produces. [14] Prednisolone is 70–90% plasma protein bound, it binds to proteins such as albumin. [14]
Prednisone: 3.5–5 0.8 16–36 Prednisolone: 4 0.8 16–36 Methylprednisolone: 5–7.5 0.5 18–40 Dexamethasone: 25–80 0 36–54 Betamethasone: 25–30 0 36–54 Triamcinolone: 5 0 12–36 Deflazacort: 6.5 – 1.3 Fludrocortisone acetate: 15 200 24 Deoxycorticosterone acetate: 0 20 – Aldosterone: 0.3 200–1000 – Beclometasone
Prednisolone acetate; Prednisolone hexanoate; Prednisolone metasulphobenzoate (prednisolone 21-(3-sulfobenzoate)) Prednisolone palmitate; Prednisolone phosphate; Prednisolone piperidinoacetate; Prednisolone pivalate; Prednisolone steaglate (prednisolone stearoyl-glycolate) Prednisolone stearoylglycolate; Prednisolone succinate (prednisolone ...
Prednisone is a prodrug and must be converted to prednisolone by the liver before it becomes active. [6] [7] Prednisolone then binds to glucocorticoid receptors, activating them and triggering changes in gene expression. [4] Prednisone was patented in 1954 and approved for medical use in the United States in 1955.
Methylprednisolone succinate, sold under the brand name Solu-Medrol among others, is a synthetic glucocorticoid corticosteroid and a corticosteroid ester—specifically the C21 succinate ester of methylprednisolone—which is used by intravenous administration.
Methylprednisolone acetate, sold under the brand names Depo-Medrol among others, is a synthetic glucocorticoid corticosteroid and a corticosteroid ester—specifically the C21 acetate ester of methylprednisolone—which is used in clinical and veterinary medicine.
Steroid ring system.. This is a list of corticosteroids (glucocorticoids and mineralocorticoids) or derivatives of cortisol (hydrocortisone).Most esters of these corticosteroids are not included in this list; for esters, see here instead.